Daily Physical Activity After Meals -Long Term Effects on Blood Glucose

NCT02536066 | Completed

• 1 other identifier: PPPA99
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The postprandial blood glucose concentration is an important risk factor for development of cardiovascular diseases and diabetes. Previous studies have shown that one bout of moderate or light post-meal physical activity effectively blunts the postprandial increase in blood glucose after carbohydrate intake. Pre-meal exercise does not generate such effect. Thus, the effect of exercise on postprandial glycemia depend on the timing of exercise. Even very light physical activity decreases postprandial glycemia when performed in the postprandial period. The purpose of this study was to investigate whether such activity performed each day for 12 weeks would influence blood variables related to glycemic control. METHODS 40 subjects being ethnic Norwegians or of South Asian origin were randomized into an intervention or a control group. They were previously diagnosed as hyperglycemic, or with high risk of type 2 diabetes according to Ramachandran's risc score. Control subjects were told to maintain their usual physical activity patterns during the study period, while the intervention subjects were instructed to undertake a minimum of 30 minutes of daily post-meal physical activity in addition to their usual activity patterns. Venous blood samples were taken before and after the 12 week intervention period. Plasma was analyzed for HbA1c and for fasting and 2hour (OGTT) values of glucose, insulin and c-peptide. The subjects kept a physical activity diary, answered questionnaires and used accelerometers to determine the level of physical activity.

Conditions

Blood Glucose; Blood Glucose Related Variables

Outcome Measures

Primary Outcomes (9)

• Change in Hba1c

  Pre and post intervention which lasts an average of 12 weeks

• Change in Fasted glucose

  Pre and post intervention which lasts an average of 12 weeks

• Change in 2hour glucose

  Oral glucose tolerance test (OGTT)

  Pre and post intervention which lasts an average of 12 weeks

• Change in glucose during OGTT

  glucose measured by finger sticks every 15. minute during the 2hour oral glucose tolerance test

  Pre and post intervention which lasts an average of 12 weeks

• Change in Physical fitness measured as heart rate during an exercise test

  Heart rate measured at the end of 10 minutes ergometer cycle test an given intensity (low) to moderate intensity)

  Measured pre and post intervention which lasts an average of 12 weeks

• Change in Physical fitness measured as oxygen consumption during an exercise test

  measured at the end of 10 minutes ergometer cycle test an given intensity (low) by indirect calorimetry

  Measured pre and post intervention which lasts an average of 12 weeks

• Change in Physical fitness measured as respiratory exchange rate during an exercise test

  Measured at the end of 10 minutes ergometer cycle test an given intensity (low), by indirect calorimetry

  Measured pre and post intervention which lasts an average of 12 weeks

• Change in Physical fitness measured as perceived exertion during an exercise test

  Borg RPE scale measured at the end of 10 minutes ergometer cycle test an given intensity (low)

  Measured pre and post intervention which lasts an average of 12 weeks

• Change in Physical fitness measured as lactic acid during an exercise test

  measured at the end of 10 minutes ergometer cycle test an given intensity (low) from capillary blod from a finger stick

  Measured pre and post intervention which lasts an average of 12 weeks

Secondary Outcomes (8)

• Change in Total cholesterol

  Measured Pre and post intervention which lasts an average of 12 weeks

• Change in LDL cholesterol

  Measured Pre and post intervention which lasts an average of 12 weeks

• Change in HDL cholesterol

  Measured Pre and post intervention which lasts an average of 12 weeks

• Change in triglycerides

  Measured Pre and post intervention which lasts an average of 12 weeks

• Change in body weight

  Measured Pre and post intervention which lasts an average of 12 weeks

Other Outcomes (2)

• Change in Level of physical activity

  Measured for 4 days pre intervention and 4 days in the middle of intervention

• Change in dietary habits

  Measured for 4 days pre intervention and 4 days in the middle of intervention

Study Arms (2)

Control

NO INTERVENTION

maintain usual physical activity patterns

Intervention

EXPERIMENTAL

Addition of daily postprandial physical activity in addition to usual activity patterns

Behavioral: Postprandial physical activity

Interventions

Postprandial physical activity BEHAVIORAL

Adding a minimum of 30 minutes of physical activity starting maximum 30 minutes after the last meal daily

Intervention

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Hyperglycemia or high risk of type 2 diabetes due to Ramachandrans risk score

You may not qualify if:

• Use of hypoglycemic agents and conditions directly affecting blood glucose other than hyperglycemia per s.e. / diabetes type 2

Sponsors & Collaborators

• Inland Norway University of Applied Sciences: lead
• University of Oslo: collaborator

Study Sites (1)

Lillehammer University College

Lillehammer, 2618, Norway

Location

Study Officials

• håvard nygaard, msc

  Inland Norway University of Applied Sciences

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 21, 2015
• First Posted: August 31, 2015
• Study Start: September 1, 2010
• Primary Completion: June 1, 2014
• Study Completion: September 1, 2014
• Last Updated: August 31, 2015

Record last verified: 2015-08

Locations

NO (1)