Effect of CVVH on NGAL in Septic AKI

NCT02536027 | Completed DMC

• 1 other identifier: FirstHospitalchenzhou
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

The plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with AKI is not affected by continuous venovenous hemofiltration (CVVH). However, it remains unclear if this also applies to sepsis-induced AKI, as considerable evidence suggests that the pathophysiology of septic AKI is different from other causes of AKI.

Conditions

Acute Kidney Injury

Keywords

continuous venovenous hemofiltration; neutrophil gelatinase-associated lipocalin; sepsis; acute kidney injury

Outcome Measures

Primary Outcomes (1)

• plasma level of neutrophil gelatinase-associated lipocalin

  The specimens in the inlet, outlet and ultrafiltrate were obtained at the beginning of CVVH (T0) and 2 h (T2h), 4 h (T4h), 8 h (T8h), and 12 h (T12h) after setup of continuous renal replacement therapy (CRRT).The plasmatic NGAL level was measured with enzyme-linked immunosorbent assay (R\&D Systems, UK, Lipocalin2/NGAL Duoset, DY1757).

  0-12 hours

Study Arms (1)

septic AKI patients

EXPERIMENTAL

septic AKI patients requiring CVVH

Procedure: continuous venovenous hemofiltration

Interventions

continuous venovenous hemofiltration PROCEDURE

Continuous renal replacement therapy (CRRT) has become routine for patients with AKI, chronic renal failure, fluid overload as well as oliguria in ICU. In clinical practice, continuous venovenous hemofiltration (CVVH) is actually the method of choice for CRRT in critically ill and hemodynamic instable patients. CVVH has significant beneficial effects on removing inflammatory cytokines, improving oxygen index, decreasing vasopressor requirements, increasing cardiac index, and regulating immune dysfunction, specifically in patients with septic shock.

Also known as: continuous renal replacement therapy

septic AKI patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Consecutive adult (\>18 years) patients with septic AKI undergoing CRRT

You may not qualify if:

• those with end-stage renal disease
• those who had undergone renal transplant
• those with cancer
• those who had contracted acquired immunodeficiency syndrome
• those who had undergone high-dose steroid treatment

Sponsors & Collaborators

• First People's Hospital of Chenzhou: lead

Related Publications (1)

• Dai X, Li T, Zeng Z, Fu C, Wang S, Cai Y, Chen Z. The effect of continuous venovenous hemofiltration on neutrophil gelatinase-associated lipocalin plasma levels in patients with septic acute kidney injury. BMC Nephrol. 2016 Oct 19;17(1):154. doi: 10.1186/s12882-016-0363-y.

  PMID: 27760529 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury; Sepsis

Interventions

Continuous Renal Replacement Therapy

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Renal Replacement Therapy; Therapeutics; Extracorporeal Circulation; Surgical Procedures, Operative

Study Officials

• Dixian DX Luo, MS

  Chenzhou First people Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Critical Care Medicine

Study Record Dates

• First Submitted: August 20, 2015
• First Posted: August 31, 2015
• Study Start: August 1, 2014
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: August 31, 2015

Record last verified: 2015-08