Brief Summary

The study pilots an outreach service for Acute kidney injury (AKI) patients, based on electronic alerts. Using the alerts we will contact the primary clinician caring for the patient with AKI in the Intervention group. The study has a control group of patients receiving good standard care, but without Outreach. The aim is to reduce morbidity and mortality in the syndrome, and also to reduce healthcare costs.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

1,865

participants targeted

Target at P75+ for not_applicable

Timeline

Completed

Started Oct 2014

Typical duration for not_applicable

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

2.7 years study duration

Study Start

First participant enrolled

October 1, 2014

Completed

6 months until next milestone

First Submitted

Initial submission to the registry

March 20, 2015

Completed

5 days until next milestone

First Posted

Study publicly available on registry

March 25, 2015

Completed

2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2017

Completed

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2017

Completed

Last Updated

February 26, 2018

Status Verified

February 1, 2018

Enrollment Period

2.7 years

First QC Date

March 20, 2015

Last Update Submit

February 23, 2018

Conditions

Acute Kidney Injury

Keywords

electronic alertsacute kidney injuryNHSmortality

Outcome Measures

Primary Outcomes (1)

Composite measure of participants not alive, need for dialysis, or progression of AKI stage
Combined endpoint
within 30 days

Study Arms (4)

After study Intervention arm Heartlands

EXPERIMENTAL

The trial has 4 arms in a Before and After design: Arm 3. After/Heartlands area patients receiving the experimental intervention Patients who have AKI and are either inpatients in the Intervention hospital or living within the surrounding catchment area are eligible. The intervention will be in the form of a telephone call to the primary clinician or visit to the patient. The intervention will include: Rapid diagnosis of AKI cause; Rapid treatment of AKI cause; Stopping 'nephrotoxic' drugs; Early nephrology followup for stage 3 AKI survivors; and preventing recurrent AKI.

Other: Rapid diagnosis of AKI causeOther: Rapid treatment of AKI causeOther: Stopping 'nephrotoxic' drugsOther: Early nephrology followup for stage 3 AKIOther: Preventing recurrent AKIOther: Good standard care

After study Control arm Good Hope

ACTIVE COMPARATOR

The trial has 4 arms in a Before and After design: Arm 4. After/Good Hope area patients observed whilst receiving active comparator Patients who have AKI, as shown by having an Alert for such, and are either inpatients in Good Hope Hospital or living within the surrounding catchment area. These patients will receive good standard care (active comparator), but none of the interventions listed for the Intervention group.

Other: Good standard care

Before study Heartlands area

ACTIVE COMPARATOR

The trial has 4 arms in a Before and After design: Arm 1. Before/Heartlands area patients observed whilst receiving active comparator Patients who have AKI, as shown by having an Alert for such, and are either inpatients in Heartlands Hospital or living within the surrounding catchment area. These patients will receive good standard care (active comparator), but none of the interventions listed for the Intervention group.

Other: Good standard care

Before study Good Hope area

ACTIVE COMPARATOR

The trial has 4 arms in a Before and After design: Arm 2. Before/Good Hope area patients observed whilst receiving active comparator Patients who have AKI, as shown by having an Alert for such, and are either inpatients in Good Hope Hospital or living within the surrounding catchment area. These patients will receive good standard care (active comparator), but none of the interventions listed for the Intervention group.

Other: Good standard care

Interventions

Rapid diagnosis of AKI causeOTHER

The Outreach team will advise on an evidence-based package of care: 1\) Rapidly establish a credible diagnosis of the cause of AKI including: 1. Improved assessment of volume status 2. Standardised use of urine dipstick . 3. Appropriate sepsis investigations. 4. Urgent ultrasound with suspected obstruction.