Treatment in Patients Hospitalized With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT02219360 | Unknown

• 1 other identifier: 2014-K-115
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic obstructive pulmonary disease has become a serious global health care and public health problems due to its high prevalence, high morbidity and heavy economic burden. Acute exacerbation of chronic obstructive pulmonary disease is one of the most important causes of death in patients with COPD. Systemic corticosteroids therapy is recommended in COPD exacerbations. In clinical practice for the treatment of acute exacerbation of COPD， antibiotic application is still controversial. Evidence from current guideline is based on strict criteria from randomized controlled trials, thus the given condition is simplified. Patients meet the criteria account for the minority in the real world. Therefore, it is still not clear whether most patients benefit from the recommended treatment. In our design, hospitalized patients with acute exacerbation of COPD will be enrolled, with their treatment, arterial hypoxemia, recovery time and length of hospitalization being observed. The main purpose is to evaluate the benefit effect of current recommended treatment of acute exacerbation of COPD in the real world.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

acute; exacerbation; chronic obstructive pulmonary disease

Outcome Measures

Primary Outcomes (1)

• change of the score of COPD Assesment Test as a measurement of the overall condition of the patient

  baseline, 1 month after dischahge, 2 months after discharge

Secondary Outcomes (1)

• change of the score of modified Medical British Research Council questionaire as a measurement of the overall condition of the patient

  baseline, 1 month after discharge, 2 months after discharge

Other Outcomes (1)

• percentage of use of systemic corticosteroid in patients

  8 months after the first enrollment

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease from 1st July, 2014 from Beijing Chao Yang Hospital

You may qualify if:

• Hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease
• Age≥ 40years old

You may not qualify if:

• The first diagnosis which caused hospitalization is not acute exacerbation of chronic obstructive pulmonary disease
• Chest radiography shows congestive heart failure
• Chest CT shows lung cancer, active pulmonary tuberculosis, pulmonary thromboembolism or interstitial lung diseases
• Serious cardiac failure, renal insufficiency or hepatic dysfunction

Sponsors & Collaborators

• Beijing Chao Yang Hospital: lead

Biospecimen

Retention: SAMPLES WITH DNA

25-(OH)-VD3 and glycated albumin will be tested

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Wang Ying, Master

  Beijing Chao Yang Hospital

  PRINCIPAL INVESTIGATOR

• Huang Kewu, M.D.

  Beijing Chao Yang Hospital

  STUDY CHAIR

Central Study Contacts

Huang Kewu, M.D.

CONTACT

86-10-85231167; kewuhuang@126.com

Wang Ying, Master

CONTACT

86-0-13426121753; kokosalaki1020@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: July 9, 2014
• First Posted: August 18, 2014
• Study Start: August 1, 2014
• Primary Completion: June 1, 2015
• Study Completion: September 1, 2015
• Last Updated: August 18, 2014

Record last verified: 2014-08