NCT01713335|Completed
Proteasis Evaluation in COPD
Pro-BPCO
Loading search results
Pro-BPCO
Sponsor study identifier
Secondary identifiers
REGISTRY · IDRCB
observational
134
1 country
1
Study Start
October 18, 2012
Actual (reported)Primary Completion
April 2017
Actual (reported)Study Completion
April 2017
Actual (reported)The aim of this study was to evaluate kallikreins and its substrate, CCN, in COPD patients. Kallikreins are a subgroup of serine proteases, enzymes which are able to cleave peptide bonds in proteins. Kallicrein profile is unkonwn in COPD. The investigators will assess Kallikrein 1 to 15 and CCN 1 to 6 in sputum of patients. Three groups of patients will be included: Healthy smoker subjects, stable COPD patients and COPD patients with acute exacerbation. Kallicrein levels in sputum will be compared in these groups.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2017
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 15, 2012
Actual (reported)October 18, 2012
Actual (reported)October 24, 2012
Actual (reported)April 2017
Actual (reported)April 2017
Actual (reported)Kallikrein level in sputum by ELISA
One sample at inclusion
Comparison between kallikrein level and clinical or functionnal parameters
All data will be identified at inclusion
Stable COPD patients were recruited from pulmonary primary care of pulmonary division of CHRU of Tours. COPD with acute exacerbation were recruited from hospitalisation of pulmonary division of CHRU of Tours and intensive care unit of CHRU of Tours.
CHRU Tours
Tours, France
Sputum
Laurent Guilleminault, MD
Service de Pneumologie, CHRU Tours, Tours, France
Valérie Gissot, MD
Centre d'Investigation Clinique, CHRU Tours, Tours, France
Antoine Guillon, MD
Service de Réanimation médicale, CHRU Tours, Tours, France
134 participants (actual enrollment reported by the registry).
First Submitted
October 15, 2012
First Posted
October 24, 2012
Study Start
October 18, 2012
Actual (reported)Bronchial Obstruction in Dairy Farmers
Contact the study team to confirm eligibility.
Primary Completion
April 2017
Actual (reported)Study Completion
April 2017
Actual (reported)Last Updated
August 26, 2021
Record last verified: 2021-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: