Sponsor study identifier
interventional
117
1 country
1
Study Start
August 2015
Actual (reported)Primary Completion
February 2018
Actual (reported)Study Completion
March 2018
Actual (reported)Currently, continuous adductor canal and popliteal-sciatic nerve blocks are used commonly for lower extremity post-operative pain control, specifically for total knee arthroplasty and foot/ankle surgery, respectively. A perineural catheter used to infuse local anesthetic for postoperative analgesia may be placed at various locations along the target nerves. Investigations of single-injection peripheral nerve blocks suggest that the onset of the block might be faster with one location over the other; but, the success rates are equivalent. However, remaining unknown is whether there is an optimal location to place a perineural catheter as part of a continuous peripheral nerve block.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2015
Actual (reported)August 9, 2015
Actual (reported)August 14, 2015
Actual (reported)February 2018
Actual (reported)March 2018
Actual (reported)September 3, 2019
Actual (reported)Pain (Average): Numeric Rating Scale for Pain
Numeric Rating Scale for Pain (0-10; 0=no pain and 10=worst imaginable pain)
Average for the day after surgery 08:00-24:00 (adductor) and the morning after surgery for 2 hours before phone call made between 10:00-noon (popliteal)
Pain (Worst) :Numeric Rating Scale for Pain
Average for the day after surgery 08:00-24:00 (adductor) and the morning after surgery for 2 hours before phone call made between 10:00-noon (popliteal)
Analgesic Use: IV Morphine Equivalents
Average for Intraoperative, in the recovery room, after the recovery room until 08:00 day after surgery, and 08:00-24:00 day after surgery
Adductor canal catheters: Inserted as described by Jæger et al., 2013: "…we performed an ultrasound survey at the medial part of the thigh, halfway between the superior anterior iliac spine and the \[superior border of the\] patella. In a short axis view, we identified the femoral artery underneath the sartorius muscle, with the vein just inferior and the saphenous nerve just lateral to the artery." Popliteal catheters: Using an ultrasound, the bifurcation of the sciatic nerve will be identified in short axis and marked at a point immediately distal at which point the two main branches of the sciatic nerve are separate and a hypoechoic area can be viewed between the two. This level will be marked on the skin. The needle will be inserted to intersect the sciatic nerve 6-7 cm proximal to the mark on the skin (therefore, proximal to the sciatic bifurcation) and injection with saline used to ensure subepimyseal spread.
Adductor canal catheters: Inserted as described by Manickam et al. 2009 Popliteal catheters: Using an ultrasound, the bifurcation of the sciatic nerve will be identified in short axis and marked at a point immediately distal at which point the two main branches of the sciatic nerve are separate and a hypoechoic area can be viewed between the two. This level will be marked on the skin. The needle tip will be inserted into the hypoechoic area between the two branches of the sciatic nerve immediately distal to the sciatic nerve bifurcation between the paraneurium and epineurium (the subparaneural space/compartment). As described by Tran et al, "An adequate position was defined as the presence of circular expansion of the paraneural sheath... Once circular expansion was obtained, we injected."
Perineural ropivacaine 0.2% at 8 mL/h (adductor) or 6 mL/h (popliteal) basal rate infusion and a 4 mL patient-controlled bolus with a 30 minute lockout
University California San Diego
San Diego, California, 92103-8770, United States
Sztain JF, Khatibi B, Monahan AM, Said ET, Abramson WB, Gabriel RA, Finneran JJ 4th, Bellars RH, Nguyen PL, Ball ST, Gonzales FB, Ahmed SS, Donohue MC, Padwal JA, Ilfeld BM. Proximal Versus Distal Continuous Adductor Canal Blocks: Does Varying Perineural Catheter Location Influence Analgesia? A Randomized, Subject-Masked, Controlled Clinical Trial. Anesth Analg. 2018 Jul;127(1):240-246. doi: 10.1213/ANE.0000000000003422.
117 participants (actual enrollment reported by the registry).
First Submitted
August 9, 2015
First Posted
August 14, 2015
Study Start
August 2015
Actual (reported)The Effect of Local Anaesthetic Volume on Nerve Block Duration and Nerve Block Duration Variability
Ambulation: Distance in Meters
Average for morning and afternoon following surgery
Pain During Afternoon Physical Therapy Session
Average during physical therapy in the afternoon following surgery
Number of Participants That Had Fluid Leakage Reported at Catheter Site.
From surgery through the day after surgery
Contact the study team to confirm eligibility.
Primary Completion
February 2018
Actual (reported)Study Completion
March 2018
Actual (reported)Last Updated
September 3, 2019
Results First Posted
September 3, 2019
Record last verified: 2019-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: