Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China

NCT02517073 | Completed DMC

• 1 other identifier: MCS-2015-008
• Study Type: observational
• Target: 104
• Locations: 1 country
• Sites: 1

Brief Summary

The mechanical ventilation strategy has changed over years worldwide. Several international researches have been conducted to study the association of the use of mechanical ventilation with clinical outcomes. In this prospective, multicenter, cross-sectional survey, the practice of mechanical ventilation among patients with severe brain injury will be investigated in 70 intensive care units in China.

Conditions

Respiration, Artificial

Keywords

mechanical ventilation; epidemiology; intensive care unit; national survey

Outcome Measures

Primary Outcomes (1)

• Number of patients receiving control and assist mode of mechanical ventilation

  Control mode is defined as volume or pressure control ventilation. Assist mode is defined as synchronized intermittent mandatory ventilation and pressure support ventilation.

  During 1 hour of on-spot survey

Secondary Outcomes (4)

• The settings of tidal volume, inspiratory pressure, and positive end-expiratory pressure in enrolled patients

  During 1 hour of on-spot survey

• Duration of mechanical ventilation

  60 days after on-spot survey

• Number of patients liberated from mechanical ventilation

  60 days after on-spot survey

• Neurological outcome by Glasgow Outcome Scale

  60 days after on-spot survey

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Mechanical ventilated patients with severe brain injury

You may qualify if:

• older than 18 years
• with severe brain injury (including severe traumatic brain injury, ischemic stroke, subarachnoid hemorrhage, spontaneous intracerebral hemorrhage, hypoxic-ischemic encephalopathy, intracranial tumor, intracranial infection and idiopathic epilepsy)
• mechanical ventilated for at least 24 hours before the time of on-spot survey

You may not qualify if:

• undergoing a spontaneous breathing trial (SBT) at the time of on-spot survey
• underwent at least once SBT in the preceding 24 hours before time of on-spot survey
• enrolled in another trial

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (1)

ICU, Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China

Location

Related Publications (1)

• Luo XY, Hu YH, Cao XY, Kang Y, Liu LP, Wang SH, Yu RG, Yu XY, Zhang X, Li BS, Ma ZX, Weng YB, Zhang H, Chen DC, Chen W, Chen WJ, Chen XM, Du B, Duan ML, Hu J, Huang YF, Jia GJ, Li LH, Liang YM, Qin BY, Wang XD, Xiong J, Yan LM, Yang ZP, Dong CM, Wang DX, Zhan QY, Fu SL, Zhao L, Huang QB, Xie YG, Huang XB, Zhang GB, Xu WB, Xu Y, Liu YL, Zhao HL, Sun RQ, Sun M, Cheng QH, Qu X, Yang XF, Xu M, Shi ZH, Chen H, He X, Yang YL, Chen GQ, Sun XM, Zhou JX; Acute Brain Injury and Critical Care Research Collaboration (ABC Research Collaboration). Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China. Chin Med J (Engl). 2016 Jul 20;129(14):1643-51. doi: 10.4103/0366-6999.185869.

  PMID: 27411450 DERIVED

MeSH Terms

Conditions

Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jian-Xin Zhou, MD

  Acute Brain Injury and Critical Care Research Collaboration, ABC Research Collaboration

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 4, 2015
• First Posted: August 6, 2015
• Study Start: August 1, 2015
• Primary Completion: August 1, 2015
• Study Completion: September 1, 2015
• Last Updated: January 28, 2016

Record last verified: 2016-01

Locations

CN (1)