A Cluster Randomized Trial to Improve Weaning and Extubation From Mechanical Ventilation in Community Hospitals
1 other identifier
interventional
N/A
1 country
11
Brief Summary
Protocol directed weaning has been shown to reduce the duration of mechanical ventilation for patients admitted to the intensive care unit (ICU) of tertiary centres. However, this benefit has not previously been studied in a community hospital setting. We therefore sought to evaluate the impact of an evidence-based weaning guideline on the outcomes for patients receiving mechanical ventilation in the ICUs of community hospitals in a cluster randomized controlled trial involving 11 community hospitals.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Jun 2003
Typical duration for phase_3
11 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2005
CompletedFirst Submitted
Initial submission to the registry
September 8, 2005
CompletedFirst Posted
Study publicly available on registry
September 12, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2006
CompletedAugust 25, 2017
August 1, 2017
2 years
September 8, 2005
August 24, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
ICU length of stay
Secondary Outcomes (7)
duration of ventilation
length of hospital stay
complications (re-intubation within 48 hours, pneumonia within 48 hours)
ICU mortality
Hospital mortality
- +2 more secondary outcomes
Interventions
Eligibility Criteria
You may qualify if:
- patients ventilated for more than 24 hours
You may not qualify if:
- patients less than 16 years of age patients who receive only non-invasive ventilation patients chronically ventilated at time of ICU admission patients who will not be candidates for weaning from ventilation at time of admission If withdrawl of life support is imminent at the point the patient has been ventilated for 24 hours
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (11)
William Osler Health Centre (Brampton)
Brampton, Ontario, N6W 2Z8, Canada
Brant Community Health Systems
Brantford, Ontario, N3R 1G9, Canada
Joseph Brant Memorial Hospital
Burlington, Ontario, L7R 4C4, Canada
Guelph General Hospital
Guelph, Ontario, N1E 4J4, Canada
St. Joseph's Health Care
London, Ontario, N6A 4V2, Canada
Trillium Health Centre
Mississauga, Ontario, L5B 1B8, Canada
North Bay General Hospital
North Bay, Ontario, P1B 5A4, Canada
Lakeridge Health Corporation (Oshawa)
Oshawa, Ontario, L1G 2B9, Canada
Stratford General Hospital
Stratford, Ontario, N5A 2Y6, Canada
St. Joseph's Health Centre
Toronto, Ontario, M9R 1B5, Canada
Hotel Dieu of St. Joseph
Windsor, Ontario, N9A 1E1, Canada
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ronald J Butler, MD
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- PRINCIPAL INVESTIGATOR
Claudio Martin, MD
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- PRINCIPAL INVESTIGATOR
Femida Gwadry-Sridhar, MSc
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 8, 2005
First Posted
September 12, 2005
Study Start
June 1, 2003
Primary Completion
June 1, 2005
Study Completion
April 1, 2006
Last Updated
August 25, 2017
Record last verified: 2017-08