Strength Training With Vascular Occlusion in Patients Harboring With HIV/Aids

NCT02783417 | Terminated DMC

• 1 other identifier: 44195315.6.0000.5393
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The use of antiretroviral therapy (ART) could prevent depression of the immune system of patients harboring with Human Immunodeficiency Virus (HIV), providing increased life expectancy, changing the classification of HIV / AIDS into a chronic illness. However prolonged use of ARTincreases the prevalence of lipodystrophy syndrome (SL), characterized by inadequate distribution of body fat and changes in lipid profile, associated with a significantly increased cardiovascular risk, among others. The practice of strength training (ST) helps in controlling SL, providing improved lipid profile and the quality of life of these patients. However, due to increased cardiovascular risk and physical weakness resulting from SL, the ST with vascular occlusion (STOV) could be a viable alternative training, to use low load (10-30% of maximal work capacity) with similar benefits ST traditional (STT), as already proven in other populations. The STOV is justified by the lower neuromuscular overhead, increasing the number of patients able to participate in this complementary therapy. The objective was to assess the impact of the combined strength training with vascular occlusion on SL and the skeletal muscle tissue in people harboring with HIV/Aids.

Conditions

Cardiovascular Diseases

Keywords

Visceral fat

Outcome Measures

Primary Outcomes (1)

• strength

  weight lifted in kg

  "pre" and "after" to "Baseline and 12 weeks"

Secondary Outcomes (1)

• Body composition

  "pre" and "after" to "Baseline and 12 weeks"

Study Arms (3)

Training with vascular occlusion

EXPERIMENTAL

Strength Training: intensity of 30% of 1RM, with vascular occlusion pressure in members.

Other: Strength Training

Traditional strength training

EXPERIMENTAL

Strength Training: intensity of 80% of 1RM, without vascular occlusion pressure in members

Other: Strength Training

Control

NO INTERVENTION

Subject untrained.

Interventions

Strength Training OTHER

G1: will be three series of repetitions to the concentric failure with occlusion pressure, with the two-second intervals for the concentric phase and two seconds for the eccentric phase (Moore et al., 2004;. LAURENTINO et al, 2012), with 30% of 1RM and intermittent vascular occlusion members. Will be provided one-minute intervals between sets and exercises (with the exception of the interval between the exercises of upper and lower; being provided at present a three-minute break for removal and installation of restrictive cuffs). G2: will be three series of repetitions to the concentric failure, with cadence of movement and intervals similar to the G1. The intensity will be 80% of 1RM without occlusion.

Traditional strength training; Training with vascular occlusion

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• After agreeing to participate in the study, patients will be interviewed and so they can be included, must meet the following criteria:
• be seropositive for HIV / AIDS and not pregnant;
• Present picture of SL;
• Aged 30-60 years (both male and female);
• Using ART, with unchanged medication in the last six months;
• With stable body weight (less than 10% change in the last six months) (DOS SANTOS, WLALDEMIR ROBERTO et al, 2013.);
• Do not present Peripheral Arterial Disease, determined by the ankle / brachial index (ABI) of less than 0.91 or greater than 1.30 (Giollo Junior, 2010);
• Who are not engaged in systematic programs of physical exercise for at least three months;
• What express voluntary agreement by signing the Informed Consent and Informed (IC).

You may not qualify if:

• They will be excluded from the study patients who:
• have any symptoms that indicate to their stay in the training program, or arising risks by doing exercises;
• miss more than six (06) training sessions not consecutively (\> 15% of the sessions) (Smart et al 2014.);
• Present framework hypertensive (blood pressure greater than 140/90 mmHg from home) during the program (Noble, 2010; NHS, 2011; MANINI et al, 2012.);
• Pass the present high risk factors for thromboembolism (MOTYKIE et al., 2000; CAPRINI, 2005); CD4 + lower levels than 200 cells / mm3 (SAIF; BONA; GREENBERG, 2001; Klein et al., 2005; CRUM-Cianflone; Weekes; BAVARO, 2008; SILVA; MORI; Guimarães, 2012), and high viral load, greater than 100,000 RNA copies / mL (CRUM-Cianflone; Weekes; BAVARO, 2008; SILVA; MORI; Guimarães, 2012); concurrent diseases classified as (1) infection (Mycobacterium avium, cytomegalovirus, Pneumocystis carinii pneumonia, the herpes simplex virus, Tuberculosis, Toxoplasmosis); (2) neoplasms (Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma), (3) autoimmune diseases (Hemolytic Anemia Autoimmune - (SAIF; BONA; GREENBERG, 2001); and (5) Ischemic Heart Disease, Aortic Stenosis Severe Obstructive Hypertrophic Cardiomyopathy and (Nakajima et al., 2006).

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

USP

Ribeirão Preto, São Paulo, 14040-900, Brazil

Location

Related Publications (2)

• Alves TC, Pugliesi Abdalla P, Bohn L, Da Silva LSL, Dos Santos AP, Tasinafo Junior MF, Rossini Venturini AC, Mota J, Lopes Machado DR. Acute and chronic cardiometabolic responses induced by resistance training with blood flow restriction in HIV patients. Sci Rep. 2022 Oct 10;12(1):16989. doi: 10.1038/s41598-022-19857-3.

  PMID: 36216952 DERIVED

• Alves TC, Santos AP, Abdalla PP, Venturini ACR, Angelotti PS, Borges FG, Reis HDO, Bollela VR, Mota J, Machado DRL. Resistance training with blood flow restriction: Impact on the muscle strength and body composition in people living with HIV/AIDS. Eur J Sport Sci. 2021 Mar;21(3):450-459. doi: 10.1080/17461391.2020.1757765. Epub 2020 May 14.

  PMID: 32349629 DERIVED

MeSH Terms

Conditions

Cardiovascular Diseases

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Resistance Training with Blood Flow Restriction

Study Record Dates

• First Submitted: May 18, 2016
• First Posted: May 26, 2016
• Study Start: August 1, 2015
• Primary Completion: February 1, 2017
• Study Completion: September 1, 2017
• Last Updated: November 1, 2017

Record last verified: 2017-10

Locations

BR (1)