NCT02498938|CompletedDMC
The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders
SA1PLG
Evaluation of SERPINA1 Gene Polymorphisms in COPD as a Risk Factor for Periodontitis
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Sponsor study identifier
observational
60
1 country
1
Study Start
March 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
November 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2015
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2015
Date type not reportedThis date has not been verified as actual or estimated.
July 13, 2015
Actual (reported)July 15, 2015
Actual (reported)November 2015
Actual (reported)December 2015
Actual (reported)SERPINA1 gene polymorphism
of blood samples and running samples by PCR
9 months
patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (\>4mm pocket probing depth)
2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
patients,both male and female aged between 30-70yrs with COPD nd chronic periodontitis
Dr. Sneha Agarwal PG(periodontics)
Hyderabad, Telangana, 500034, India
Scott DA, von Ahsen N, Palmer RM, Wilson RF. Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis. J Clin Periodontol. 2002 Dec;29(12):1118-21. doi: 10.1034/j.1600-051x.2002.291212.x.
Travis J, Pike R, Imamura T, Potempa J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S143-6. doi: 10.1164/ajrccm/150.6_Pt_2.S143.
2ml of blood sample from each subject will be collected in EDTA containing vials and kept at -20 degrees until DNA extraction. the genomic DNA will be isolated and Z/S polumorphism in SERPINA1 gene will be identified by PCR followed by restriction digestion pattern by Alu 1 restriction enzyme.
Dr. Sneha Agarwal, PG(perio)
Panineeya Mahavidyalaya institute of dental sciences and research centre
60 participants (actual enrollment reported by the registry).
First Submitted
July 13, 2015
First Posted
July 15, 2015
Study Start
March 2015
Date type not reportedThis date has not been verified as actual or estimated.
Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2
Contact the study team to confirm eligibility.
Primary Completion
November 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Last Updated
August 29, 2016
Record last verified: 2016-08
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Source: ClinicalTrials.gov.
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