Validation of the 1-minute Sit-to-stand Test in Patients With COPD

NCT02441725 | Completed

• 1 other identifier: STAND-UP Study
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

This is a study to provide an in-depth validation of the 1-minute sit-to-stand test as a measure of exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Patients will perform the 1-minute sit-to-stand test and other validated exercise tests and questionnaires.

Conditions

Pulmonary Disease, Chronic Obstructive

Outcome Measures

Primary Outcomes (1)

• 1-minute sit-to-stand test

  Number of repetitions performed in the 1-minute sit-to-stand test

  Change from baseline after pulmonary rehabilitation programme

Secondary Outcomes (17)

• 5-repetition sit-to-stand test

  Change from baseline after pulmonary rehabilitation programme

• 6-minute walk test

  Change from baseline after pulmonary rehabilitation programme

• Quadriceps maximal voluntary contraction force

  Change from baseline after pulmonary rehabilitation programme

• Chronic Respiratory Questionnaire

  Change from baseline after pulmonary rehabilitation programme

• Hospital Anxiety and Depression Scale

  Change from baseline after pulmonary rehabilitation programme

Study Arms (2)

Pulmonary Rehabilitation Patients

OTHER

Validation of the 1-minute sit-to-stand test; for participants who consent including a extended daily assessment period of physical activity and patient-reported symptoms of exacerbations: Male and female COPD inpatients (≥40 years of age) from two pulmonary rehabilitation clinics (Klinik Barmelweid and Zürcher Höhenklinik Wald)

Other: 1-minute sit-to-stand test

Acute Care Hospital Patients

OTHER

Validation of the 1-minute sit-to-stand test, including daily assessment of physical activity and patient-reported symptoms of exacerbations: Male and female COPD inpatients from two acute care hospitals (≥40 years of age; Stadtspital Waid and Spital Uster)

Other: 1-minute sit-to-stand test

Interventions

1-minute sit-to-stand test OTHER

Validation of the 1-minute sit-to-stand test in a COPD patient population

Acute Care Hospital Patients; Pulmonary Rehabilitation Patients

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• COPD diagnosis according to GOLD criteria; post bronchodilator FEV1/FVC\<70%
• Male and female patients ≥40 years of age
• Able to do at least 5 repetitions in the 1-min STS test at baseline assessment
• Written informed consent by the participant

You may not qualify if:

• Lower limb joint surgery in the preceding 3 months
• Too unstable medically to perform exercise tests
• Predominant neurological or musculoskeletal limitation to walking
• Cognitive reading impairment and/or difficulties managing the eDiary and step-counter

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University of Zurich

Zurich, 8001, Switzerland

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Anja Frei, pHd

  University of Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 29, 2015
• First Posted: May 12, 2015
• Study Start: April 1, 2015
• Primary Completion: May 1, 2016
• Study Completion: May 1, 2016
• Last Updated: October 25, 2016

Record last verified: 2016-10

Locations

CH (1)