A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

NCT02273128 | Completed DMC

• 1 other identifier: D129206005
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

Conditions

Generalized Chronic Periodontitis; Osteoporosis

Keywords

Osteoporosis; Chronic Periodontitis; Calcitonin gene Polymorphism

Outcome Measures

Primary Outcomes (1)

• Calcitonin gene polymorphism

  Collection of blood samples and running the samples by PCR

  5 Months

Study Arms (1)

CTR Gene in Osteoporosis and Periodontitis

Patients aged between 35 - 60 yrs with Osteoporosis (BMD\>-2.5) and Chronic Periodontitis (\>3mm Pocket Probing Depth)

Genetic: CTR Gene

Interventions

CTR Gene GENETIC

2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism

Also known as: Calcitonin Gene, Hypocalcaemic agent

CTR Gene in Osteoporosis and Periodontitis

Eligibility Criteria

• Age: 35 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients both male and female aged between 35-60 Years with Osteoporosis and Chronic Periodontitis.

You may qualify if:

• Male and Female
• Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study

You may not qualify if:

• Patients who are Systemically compromised and under medications such as steroids.
• Patients who smoke.Pregnant and lactating mothers are excluded from the study

Sponsors & Collaborators

• Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre: lead

Study Sites (1)

Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre

Hyderabad, Andhra Pradesh, 500060, India

Location

Biospecimen

Retention: SAMPLES WITH DNA

2ml of blood sample from each subject was collected in EDTA containing vials and kept at -20 degrees until DNA extraction. The genomic DNA was isolated and C/T polymorphism in CTR gene was identified by PCR followed by restriction digestion pattern by Alu 1 restriction enzyme.

MeSH Terms

Conditions

Osteoporosis; Chronic Periodontitis

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Dr.Anuradha Ankam, PG(Perio)

  Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post Graduate

Study Record Dates

• First Submitted: October 21, 2014
• First Posted: October 23, 2014
• Study Start: June 1, 2014
• Primary Completion: October 1, 2014
• Study Completion: November 1, 2014
• Last Updated: April 21, 2015

Record last verified: 2015-04

Locations

IN (1)