Obesity and Lipids: a Matter of Taste?

NCT02497274 | Completed

• 2 other identifiers: C14-772015-A00906-43
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of the protocol is to determine the impact of bariatric surgery on taste receptors and taste perceptions and to precise the factors implicated in taste alterations in 50 obese patients before and 6 months after bariatric surgery (25 Roux Y gastric bypass and 25 sleeve gastrectomy).

Conditions

Obesity

Keywords

bariatric surgery; taste perception; lipid receptors

Outcome Measures

Primary Outcomes (1)

• Expression of lipid receptors

  To compare the expression of lipid receptors expressed in the taste buds before and after a significant weight loss induced by bariatric surgery

  before and 6 months after bariatric surgery

Secondary Outcomes (1)

• Lipids thresholds

  before and 6 months after bariatric surgery

Other Outcomes (2)

• Factors associated with taste perception

  before and 6 months after bariatric surgery

• Influence of surgical technique on taste perception

  before and 6 months after bariatric surgery

Study Arms (2)

Roux Y gastric bypass

EXPERIMENTAL

candidates for bariatric surgery by Roux Y gastric bypass with taste assessment and epithelium gustatory smear and biopsy

Other: taste assessment and epithelium gustatory smear and biopsy

Sleeve gastrectomy

EXPERIMENTAL

candidates for bariatric surgery by sleeve gastrectomy with taste assessment and epithelium gustatory smear and biopsy

Other: taste assessment and epithelium gustatory smear and biopsy

Interventions

taste assessment and epithelium gustatory smear and biopsy OTHER

assessment of taste perceptions and expression of taste receptors before and after bariatric surgery and epithelium gustatory smear and biopsy

Roux Y gastric bypass; Sleeve gastrectomy

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Affiliation to a health insurance
• Patients candidates for bariatric surgery based on criteria established by international experts (BMI\> 40 or\> 35 kg / m² with severe comorbidities, after failure of multidisciplinary care for a period of at least 1 year)
• Written consent after oral and written informations

You may not qualify if:

• Topic guardianship, curatorship or safeguard justice.
• Taking a treatment known to alter the perception of taste
• Oral Decay can affect the perception of taste
• Treatment that may interfere with intestinal peptides or lipids receptors (especially DDP4 inhibitors, anti-inflammatory medications, intestinal lipase inhibitors: Xenical)
• Tobacco use, alcohol or drugs abuse
• Known coagulopathy, abnormal hemostasis tests or abnormal platelets count, treatment interfering with coagulation or platelet aggregation
• Contraindication to bariatric surgery
• Malignant pathology, severe liver disease or severe inflammatory disease, malabsorption.
• Pregnancy
• Positive serology for VIH, VBH and CVH

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Related Publications (3)

• Bernard A, Le Beyec-Le Bihan J, Radoi L, Coupaye M, Sami O, Casanova N, Le May C, Collet X, Delaby P, Le Bourgot C, Besnard P, Ledoux S. Orosensory Perception of Fat/Sweet Stimuli and Appetite-Regulating Peptides before and after Sleeve Gastrectomy or Gastric Bypass in Adult Women with Obesity. Nutrients. 2021 Mar 8;13(3):878. doi: 10.3390/nu13030878.

  PMID: 33800516 RESULT

• Bernard A, Richard C, Radoi L, Boidot R, Ledoux S, Besnard P. Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery. Obesity (Silver Spring). 2025 Aug;33(8):1518-1528. doi: 10.1002/oby.24325. Epub 2025 Jun 22.

  PMID: 40545805 RESULT

• Bernard A, Radoi L, Christensen J, Servant F, Blasco-Blaque V, Ledoux S, Collet X, Besnard P. A specific tongue microbiota signature is found in patients displaying an improvement of orosensory lipid perception after a sleeve gastrectomy. Front Nutr. 2023 Jan 11;9:1046454. doi: 10.3389/fnut.2022.1046454. eCollection 2022.

  PMID: 36712531 RESULT

MeSH Terms

Conditions

Obesity

Interventions

Biopsy

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Specimen Handling; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Séverine Ledoux

  APHP-INSERM

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2015
• First Posted: July 14, 2015
• Study Start: January 11, 2016
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: November 18, 2025

Record last verified: 2021-08