Isometric Handgrip Exercise for Blood Pressure Management

NCT02458443 | Completed

• 1 other identifier: UNewEngland
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Recent meta-analyses suggest isometric resistance training (IRT) may be superior to aerobic exercise for lowering blood pressure. The investigators intend to conduct the largest, longest, prospective, double-blind randomized controlled trial using isometric resistance training to reduce blood pressure to reduce hypertension.

Conditions

Hypertension

Outcome Measures

Primary Outcomes (1)

• Change in systolic and diastolic blood pressure

  Change measures: baseline and 12 weeks

Secondary Outcomes (2)

• Compare and contrast change in systolic and diastolic blood pressure of medicated and un-medicated participants

  Baseline and 12 weeks

• Detraining effects, changes in systolic and diastolic blood pressure after cessation of Isometric Resistance Training

  12 weeks and 24 weeks

Study Arms (4)

IHG 5% Un-medicated

SHAM COMPARATOR

Participants with high blood pressure (greater than 120/80) who are not medicated for blood pressure control will conduct isometric handgrip (IHG) exercise at 5% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Other: Isometric resistance training

IHG 5% BB

SHAM COMPARATOR

Participants with high blood pressure (greater than 120/80) who are currently taking beta blockers for blood pressure control will conduct isometric handgrip exercise at 5% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Other: Isometric resistance training

IHG 30% Un-medicated

EXPERIMENTAL

Participants with high blood pressure (greater than 120/80) who are not medicated for blood pressure control will conduct isometric handgrip exercise at 30% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Other: Isometric resistance training

IHG 30% BB

EXPERIMENTAL

Participants with high blood pressure (greater than 120/80) who are currently taking beta blockers for blood pressure control will conduct isometric handgrip exercise at 30% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session.

Other: Isometric resistance training

Interventions

Isometric resistance training OTHER

Isometric handgrip exercise using a hand dynamometer

IHG 30% BB; IHG 30% Un-medicated; IHG 5% BB; IHG 5% Un-medicated

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Blood pressure above 120/80 currently not taking anti-hypertensive medications whose doctor has suggested would benefit from exercise; and
• people currently taking beta blockers for blood pressure management.

You may not qualify if:

• Younger than 30yrs and older than 70 yrs;
• unable to voluntary participate;
• unable to participate under doctor's recommendation;
• smokers;
• arthritis or carpal tunnel which may be aggravated with handgrip exercise;
• known cardiovascular disease (angina) and the following co-morbid conditions:
• obesity,
• insulin resistance,
• depression,
• mobility impairment,
• sleep apnoea,
• fatty liver disease or
• renal disease

Sponsors & Collaborators

• University of New England, Australia: lead

Study Sites (1)

UNE Exercise Physiology Lab

Armidale, New South Wales, 2351, Australia

Location

Related Publications (1)

• Carlson DJ, Dieberg G, Hess NC, Millar PJ, Smart NA. Isometric exercise training for blood pressure management: a systematic review and meta-analysis. Mayo Clin Proc. 2014 Mar;89(3):327-34. doi: 10.1016/j.mayocp.2013.10.030.

  PMID: 24582191 BACKGROUND

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Neil Smart, PhD

  University of New England

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Sponsor-Investigator

Study Record Dates

• First Submitted: May 21, 2015
• First Posted: June 1, 2015
• Study Start: February 1, 2016
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: December 17, 2020

Record last verified: 2020-12

Locations

AU (1)