Pharmacists Intervention to Improve Hypertension Management in Primary Care
APOTHECARE
1 other identifier
interventional
497
1 country
54
Brief Summary
Arterial hypertension is the single largest contributor to mortality world-wide, and only 30-50% of diagnosed and treated patients achieve their blood pressure goal. The APOTHECARE trial is designed to identify treated patients with uncontrolled hypertension in community pharmacies in order to improve blood pressure control through intensification of antihypertensive therapy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable hypertension
Started Oct 2017
Typical duration for not_applicable hypertension
54 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 5, 2017
CompletedFirst Posted
Study publicly available on registry
September 7, 2017
CompletedStudy Start
First participant enrolled
October 16, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedApril 7, 2020
April 1, 2020
2.2 years
September 5, 2017
April 5, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Proportion of patients with systolic blood pressure <135 mmHg and diastolic blood pressure < 85 mmHg at 10 weeks of follow-up (automated office blood pressure measurement)
Primary endpoint
10 weeks
Secondary Outcomes (4)
Change in average systolic blood pressure (automated office blood pressure measurement)
10 weeks
Change in average systolic blood pressure (automated office blood pressure measurement)
20 weeks
Proportion of patients with systolic blood pressure <135 mmHg and diastolic blood pressure < 85 mmHg (automated office blood pressure measurement)
20 weeks
Proportion of patients with systolic blood pressure <135 mmHg and diastolic blood pressure < 85 mmHg (home blood pressure, mean of available readings)
20 weeks
Study Arms (2)
Interventional Arm
EXPERIMENTALImmediate referral of hypertensive patients to the attending physician based on automated office blood pressure measurements
Observational Arm
NO INTERVENTIONRepeated automated office blood pressure measurements and referral of hypertensive patients to the attending physician after completion of the trial
Interventions
Immediate referral to the treating physician in case of elevated automated office blood pressure measurements
Eligibility Criteria
You may qualify if:
- Written informed consent
- Age \> 18 years
- Medically pre-treated arterial hypertension
- Automated office blood pressure ≥ 135 mmHg systolic or ≥ 85 mmHg diastolic
You may not qualify if:
- First ever prescription of antihypertensive medication
- First prescription of a new antihypertensive substance or dose adjustment
- Prior therapy with 4 or more different antihypertensive substances
- Systolic blood pressure ≥ 180 mmHg
- Dialysis
- Adherence to the study protocol not to be anticipated
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (54)
Buchen-Apotheke
Alland, 2534, Austria
Apotheke Bad Erlach
Bad Erlach, 2822, Austria
Kur-Apotheke
Bad Vöslau, 2540, Austria
Landschafts-Apotheke
Baden, 2500, Austria
Apotheke Am Goettweiger
Furth, 3511, Austria
Oetscherland-Apotheke
Gaming, 3292, Austria
Apotheke zum heiligen Georg
Gaweinstal, 2191, Austria
Apotheke Gmuend Neustadt
Gmünd, 3950, Austria
Apotheke Zum Auge Gottes
Gmünd, 3950, Austria
Marien-Apotheke
Gramatneusiedl, 2440, Austria
St. Georgs-Apotheke
Himberg, 2325, Austria
Apotheke Zu Maria Trost
Kirchberg am Wagram, 3470, Austria
Stadt-Apotheke
Klosterneuburg, 3400, Austria
Die Blaue Apotheke
Klosterneuburg, 3412, Austria
Kreis-Apotheke Zum schwarzen Adler
Korneuburg, 2100, Austria
Adler-Apotheke
Langenlois, 3550, Austria
Kamptal-Apotheke
Langenlois, 3550, Austria
Kronen-Apotheke
Lilienfeld, 3180, Austria
Apotheke Zur Madonna
Neunkirchen, 2620, Austria
Merkur-Apotheke
Neunkirchen, 2620, Austria
Triesting-Apotheke,
Oberwaltersdorf, 2522, Austria
Apotheke Zum heiligen Georg
Pitten, 2823, Austria
Apotheke Zum St. Nikolaus
Pottendorf, 2486, Austria
Apotheke Zur Mariahilf
Pöggstall, 3650, Austria
Apotheke Purgstall
Purgstall, 3251, Austria
Wallhof-Apotheke
Rannersdorf, 2324, Austria
Apotheke Sued
Sankt Pölten, 3100, Austria
Center Apotheke
Sankt Pölten, 3100, Austria
Hippolyt-Apotheke
Sankt Pölten, 3100, Austria
Rosen-Apotheke
Sankt Pölten, 3100, Austria
Stadt-Apotheke
Schrems, 3943, Austria
Linden-Apotheke
Seitenstetten Markt, 3353, Austria
Johannes-Apotheke
Traisen, 3160, Austria
Apotheke Zur Mutter Gottes
Traismauer, 3133, Austria
Activ Apotheke Tribuswinkel
Tribuswinkel, 2512, Austria
Urania Apotheke
Vienna, 1010, Austria
Siebenbrunnen Apotheke
Vienna, 1050, Austria
Heilfried Apotheke
Vienna, 1100, Austria
Ludwigs Apotheke
Vienna, 1110, Austria
Friedrichs Apotheke
Vienna, 1170, Austria
Linden Apotheke
Vienna, 1170, Austria
Adler Apotheke
Vienna, 1180, Austria
Arkaden Apotheke
Vienna, 1200, Austria
Rosen Apotheke
Vienna, 1210, Austria
Apotheke Neu Kagran
Vienna, 1220, Austria
St. Hubertus Apotheke
Vienna, 1220, Austria
Birken Apotheke
Vienna, 1230, Austria
Apotheke Zur Mariahilf
Wiener Neustadt, 2700, Austria
Bahnhof-Apotheke
Wiener Neustadt, 2700, Austria
Zehnerguertel-Apotheke
Wiener Neustadt, 2700, Austria
Apotheke Wimpassing
Wimpassing, 2632, Austria
Apotheke Zur heiligen Dreifaltigkeit
Wolkersdorf, 2120, Austria
Apotheke Zum schwarzen Adler
Zwettl Stadt, 3910, Austria
Kuenringer Apotheke
Zwettl Stadt, 3910, Austria
Related Publications (1)
Rohla M, Haberfeld H, Tscharre M, Huber K, Weiss TW. Pharmacist interventions to improve blood pressure control in primary care: a cluster randomised trial. Int J Clin Pharm. 2023 Feb;45(1):126-136. doi: 10.1007/s11096-022-01452-1. Epub 2022 Nov 8.
PMID: 36346543DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Miklos Rohla, MD
3rd Medical Department, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria
- STUDY CHAIR
Thomas W Weiss, MD, PhD
3rd Medical Department, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Vienna, Austria
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
September 5, 2017
First Posted
September 7, 2017
Study Start
October 16, 2017
Primary Completion
December 31, 2019
Study Completion
December 31, 2019
Last Updated
April 7, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share