Risk Factors of Postoperative Acute Lung Injury Following Liver Transplantation

NCT02412800 | Unknown

• 1 other identifier: 201412036RINC
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative acute lung injury (ALI) during the first 72 hours after liver transplantation is not uncommon. Injury may occur because liver transplantation is often associated with prolonged operative time, large volumes of fluid administration and transfusion, as well as inflammatory responses related to ischemia-reperfusion injury. For more precise perioperative fluid and hemodynamic management, modern monitoring systems, such as the pulse contour cardiac output (PiCCO) system, have been devised and reported in recent years. The PiCCO system uses the thermodilution technique to determine the cardiac index (CI) and thoracic fluid indices such as the intrathoracic blood volume index (ITBVI), extravascular lung water index (EVLWI), and pulmonary vascular permeability index (PVPI), all of which may reflect pulmonary fluid and injury status. However, perioperative changes in thoracic fluid indices in liver transplantation and their associations with postoperative ALI are not yet clear. In this study, the investigators aimed to determine patterns of change in perioperative thoracic fluid indices and compare these changes in recipients who did or did not develop postoperative ALI. Furthermore, the investigators will also try to determine the potential risk factors following liver transplantation.

Conditions

Acute Lung Injury

Keywords

Extravascular lung water; Pulmonary vascualr permeability index; Liver transplantation

Outcome Measures

Primary Outcomes (1)

• Postoperative acute lung injury

  72 hours

Study Arms (1)

Acute lung injury

Postoperative acute lung injury was diagnosed according to the latest 2012 Berlin definition of acute respiratory distress syndrome by the PaO2/FiO2\< 300 and acute onset of bilateral infiltrates on the chest radiograph that were not fully explained by cardiac failure during postoperative day 1 to postoperative day 3.

Eligibility Criteria

• Age: 6 Months - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Liver transplant recipients in NTUH, Taipei, Taiwan. From 2004-2014.

You may qualify if:

• End stage liver disease receiving liver transplantation in NTUH.
• Age: 6 months old to 75 years old

You may not qualify if:

• history of pulmonary resection,
• chronic respiratory insufficiency
• cardiac dysfunction
• failure of the surgery.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Conditions

Acute Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Kuang Cheng Chan, M.D.

  Natioanal Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kuang Cheng Chan, M.D.

CONTACT

+886-2-23123456; jkjchan@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 6, 2015
• First Posted: April 9, 2015
• Study Start: April 1, 2015
• Primary Completion: January 1, 2016
• Study Completion: January 1, 2016
• Last Updated: October 29, 2015

Record last verified: 2015-10

Locations

TW (1)