NCT01922557

Brief Summary

To study the association of the thoracic fluid content and acute lung injury during liver transplantation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jan 2011

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2011

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2011

Completed
1.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2012

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

July 11, 2013

Completed
1 month until next milestone

First Posted

Study publicly available on registry

August 14, 2013

Completed
Last Updated

August 14, 2013

Status Verified

August 1, 2013

Enrollment Period

Same day

First QC Date

July 11, 2013

Last Update Submit

August 12, 2013

Conditions

Acute Lung Injury

Outcome Measures

Primary Outcomes (1)

  • Cardiac index

    Participants will be followed for the duration the operation. Cardiac index was measured by non-invasive cardiac output monitor at different time points as baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4)

    one day

Secondary Outcomes (1)

  • Thoracic fluid content

    one day

Study Arms (1)

NICOM

Device: NICOM

Interventions

NICOMDEVICE

NICOM monitoring thoracic fluid content at baseline(T1), anhepatic phase(T2), 30 mins after reperfusion(T3) and 2 hrs after reperfusion(T4).

NICOM

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

end stage liver disease patients scheduled for liver transplantation in National Taiwan University Hospital were enrolled.

You may qualify if:

  • end stage liver disease scheduled for liver transplantation in National Taiwna University Hospital.

You may not qualify if:

  • allergic reaction
  • history of aortic regurgitation
  • pre-existing pulmonary disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Anesthesiology, NTUH

Taipei, 100, Taiwan

Location

Related Publications (1)

  • Hong SK, Hwang S, Lee SG, Lee LS, Ahn CS, Kim KH, Moon DB, Ha TY. Pulmonary complications following adult liver transplantation. Transplant Proc. 2006 Nov;38(9):2979-81. doi: 10.1016/j.transproceed.2006.08.090.

    PMID: 17112879BACKGROUND

MeSH Terms

Conditions

Acute Lung Injury

Condition Hierarchy (Ancestors)

Lung InjuryLung DiseasesRespiratory Tract Diseases

Study Officials

  • Kuang Cheng Chan, M.D.

    Department of Anesthesiology, NTUH, Taipei, Taiwan

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 11, 2013

First Posted

August 14, 2013

Study Start

January 1, 2011

Primary Completion

January 1, 2011

Study Completion

June 1, 2012

Last Updated

August 14, 2013

Record last verified: 2013-08

Locations

TW(1)