Airway Pressure During Humidified High Flow Nasal Cannula Therapy in Children

NCT02387632 | Completed DMC

• 1 other identifier: 15-079
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Humidified High Flow Nasal Cannula (HHFNC) is a new modality of respiratory support for children with respiratory failure. Despite its extensive use in pediatric and adult population, the exact mechanism of work of HHFNC is not fully explained.The objective of the investigators' research project is to determine the relationship between the amount of airway pressure that can be delivered at specific flow levels of HHFNC. This information will allow the investigators to use HHFNC in a much more informed and safe manner.

Conditions

Bronchiolitis; Pneumonia; Bronchial Asthma

Outcome Measures

Primary Outcomes (1)

• Airway pressure measurement

  oesophageal pressure will be measured as a surrogate of airway pressure using Nasogastric tube liquid filled technique.

  will be measured at start of HHFNC therapy and with titration of flow rate.

Secondary Outcomes (1)

• predictors of positive airway pressure delivery.

  will be measured simultaneously with airway pressure

Eligibility Criteria

• Age: 2 Weeks - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Children under 18 years, admitted to PCCU, who require respiratory support using HHFNC, as determined by the caring physician; and informed consent of substitute decision maker will be included in the study.

You may qualify if:

• Aged less than 18 years, admitted to PCCU with acute respiratory distress.
• HHFNC respiratory support prescribed by the caring physician.
• Requirement for a size 10 French or smaller nasogastric (NG) or orogastric (OG) tube, as prescribed by the caring physician.
• Informed consent, and/- or assent where appropriate.

You may not qualify if:

• Continuous or intermittent NG or OG tube suction is required.

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

McMaster Children's Hospital

Hamilton, Ontario, L8N 3Z5, Canada

Location

MeSH Terms

Conditions

Bronchiolitis; Pneumonia; Asthma

Condition Hierarchy (Ancestors)

Bronchitis; Respiratory Tract Infections; Infections; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Karen Choong, FRCP(C)

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 8, 2015
• First Posted: March 13, 2015
• Study Start: June 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: March 6, 2019

Record last verified: 2015-11

Locations

CA (1)