A Polymerase Chain Reaction (PCR) - Based Method to Improve Antibiotic Prescribing for Pneumonia

NCT00867841 | Withdrawn

• 1 other identifier: CHEO-ID-001
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Pneumonia, or lung infection, is usually treated with antibiotics targeted against the organisms that the physician guesses are causing the problem. The determination of the exact cause of a patient's pneumonia is difficult. The problem is that the two major causes of community-acquired pneumonia are not easily distinguished on clinical grounds and are best treated by different antibiotics. The investigators hypothesize that antibiotic therapy can be targeted and improved by doing polymerase chain reaction (PCR) testing of nose swabs to identify probable implicated organisms and their antibiotic resistance patterns. This pilot study will be important to ensure that the laboratory testing is functional and that the emergency department-laboratory communication is optimal prior to doing a full-fledged randomized clinical trial.

Conditions

Pneumonia

Keywords

pneumonia, community-acquired; polymerase chain reaction; pneumococcus; mycoplasma; chlamydophila; anti-bacterial agents

Study Arms (1)

Pneumonia

Children diagnosed with community-acquired pneumonia by the emergency department physician

Procedure: nasopharyngeal swab

Interventions

nasopharyngeal swab PROCEDURE

PCR of NP swab for Mycoplasma, Chlamydophila, pneumococcus, pneumococcus macrolide resistance genes.

Pneumonia

Eligibility Criteria

• Age: 180 Days+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

children with community-acquired pneumonia presenting to the Children's Hospital of Eastern Ontario emergency department

You may qualify if:

• presumed community-acquired pneumonia as diagnosed by the attending emergency department physician

You may not qualify if:

• age \> 6 months
• immunodeficiency (primary, advanced HIV)
• cystic fibrosis
• malignancy
• known cardiac or lung defects
• bronchiectasis
• previous pneumonia or lung abscess in past 6 months
• conditions requiring treatment with immune suppressants

Sponsors & Collaborators

• Children's Hospital of Eastern Ontario: lead
• The Physicians' Services Incorporated Foundation: collaborator

Study Sites (1)

Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1, Canada

Location

Related Publications (26)

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Biospecimen

Retention: SAMPLES WITH DNA

nasopharyngeal swabs blood samples (for pneumococcal PCR)

MeSH Terms

Conditions

Pneumonia; Community-Acquired Pneumonia; Mycoplasma Infections; Chlamydia Infections

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases; Community-Acquired Infections; Mycoplasmatales Infections; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Chlamydiaceae Infections; Sexually Transmitted Diseases, Bacterial; Sexually Transmitted Diseases; Communicable Diseases; Genital Diseases; Urogenital Diseases

Study Officials

• Jeffrey Pernica, MD

  Children's Hospital of Eastern Ontario/University of Ottawa

  PRINCIPAL INVESTIGATOR

• Robert Slinger, MD

  Children's Hospital of Eastern Ontario/University of Ottawa

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 23, 2009
• First Posted: March 24, 2009
• Last Updated: February 25, 2016

Record last verified: 2016-02

Locations

CA (1)