Arterial Stiffness and AKI Post-CABG

NCT02364427 | Completed

• 1 other identifier: KCH heart-AKI
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

Acute Kidney Injury is a condition where your kidneys suddenly stop working properly and usually occurs if you are already unwell with an illness and can happen after having surgery. Having an episode of acute kidney injury increases the risk of progression to chronic kidney disease (CKD) later on and decreases long-term survival. It also has a major socioeconomic impact with regards to admissions and length of hospital stay. There is currently no universally accepted treatment or method of identifying patients that are at risk. The investigators aim to measure arterial stiffness in patients prior to them undergoing cardiac surgery to investigate whether this measurement is associated with an increased risk of patients developing acute kidney injury after surgery. The investigators are planning to measure arterial stiffness, and examine a blood sample, for kidney health-related levels to determine whether there is an association between those patients who have stiff arterial vessels and those patients who may develop acute kidney injury after surgery.

Conditions

Acute Kidney Injury

Keywords

Pulse wave velocity; Arterial stiffness; AKI

Outcome Measures

Primary Outcomes (1)

• Pulse Wave Velocity (arterial stiffness)

  Baseline visit

Secondary Outcomes (1)

• Kidney function measured by renal blood profile

  baseline

Study Arms (1)

Arterial stiffness

Arterial stiffness - Vicorder to measure pulse wave velocity

Device: Arterial stiffness - Vicorder to measure pulse wave velocity

Interventions

Arterial stiffness - Vicorder to measure pulse wave velocity DEVICE

Pulse wave velocity (PWV)measures the stiffness of the arteries. This provides a simple and quick noninvasive method of obtaining the PWV for an arterial segment.

Also known as: Vicorder

Arterial stiffness

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients undergoing pure (non-valvular repair) CABG surgery

You may qualify if:

• All patients undergoing pure (non-valvular repair) CABG surgery
• Male or female
• Aged \>18 years
• Written informed consent

You may not qualify if:

• Patients who have aortic grafts or renal stents
• Patients at CKD stage 4 or 5 or on dialysis
• Bilateral amputee
• Unable to lie supine for 10-15 mins
• Psychiatric illness, including anxiety, mood and untreated eating disorders
• Infection or course of antibiotics within the last month

Sponsors & Collaborators

• King's College Hospital NHS Trust: lead

Study Sites (1)

King's College Hospital

London, SE5 9RS, United Kingdom

Location

Related Publications (1)

• Greenwood SA, Mangahis E, Castle EM, Wang J, Campbell J, Deshpande R, Jayawardene S. Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery. J Cardiothorac Surg. 2019 Mar 7;14(1):51. doi: 10.1186/s13019-019-0873-3.

  PMID: 30845970 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Sharlene A Greenwood, PhD

  Consultant renal physiotherapist

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 4, 2015
• First Posted: February 18, 2015
• Study Start: April 1, 2015
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: March 11, 2019

Record last verified: 2018-03

Locations

GB (1)