Epidemiology of Acute Kidney Injury in England - 1998 to 2013

NCT02216695 | Completed Results

• 1 other identifier: 1.2
• Study Type: observational
• Target: 64,882
• Locations: 1 country
• Sites: 1

Brief Summary

The true population incidence of acute kidney injury (AKI), previously called acute renal failure, in England is not known. A better understanding of the epidemiology of AKI at a national level is essential to inform initiatives to prevent AKI as well as reduce the associated morbidity and mortality. The purpose of this study is to combine the national database of all hospital discharges with national census data to investigate trends in the incidence of both, AKI not requiring dialysis and AKI requiring dialysis, as well as its associated mortality and its determinants in England between 1998 and 2013

Conditions

Acute Kidney Injury

Keywords

acute kidney injury; epidemiology; mortality

Outcome Measures

Primary Outcomes (2)

• Secular Trends in the Mortality After Acute Kidney Injury From 1998 to 2013

  A retrospective cohort study of patients with acute kidney injury in England over a period of fifteen years, describing the trends in the mortality of acute kidney injury.

  Participants will be followed for the duration of hospital stay (average of 15 days)

• Incidence of AKI-D From 1998-9 to 2012-13

  The population incidence of acute kidney injury requiring dialysis (AKI-D) was calculated using mid-year population of England in each year from 1998 to 2013 and expressed as people per million population. This was calculated by dividing number of cases by mid year population of England and multiplying by million.

  15-years

Secondary Outcomes (2)

• Mortality From Acute Kidney Injury in Each Age Group From 1998 to 2013

  Participants will be followed for the duration of hospital stay (average 13 days)

• Mortality From Acute Kidney Injury in Each Five-year Period From 1998 to 2013

  Participants will be followed for the duration of hospital stay (average 13 days)

Eligibility Criteria

• Age: 1 Day - 120 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a historical cohort study using already collected data from the Hospital Episode Statistics (HES), a data warehouse containing details of all admissions, outpatient appointments and A\&E attendances at NHS hospitals in England.

You may qualify if:

• Patients with any of the following ICD 10 codes, in any of the diagnoses, in the HES database, will be included: N17.0 for acute renal failure with tubular necrosis, N17.1 for acute renal failure with acute cortical necrosis, N17.2 for acute renal failure with medullary necrosis, N17.8 for other acute renal failure and N17.9 for acute renal failure, unspecified.
• All patients of any age and gender, with AKI as identified as above between the period of 1st April 1998 and 31st March 2013.

You may not qualify if:

• Patients with any of the following codes in any of the diagnoses codes will be excluded: N18.5 for chronic kidney disease stage 5, N18.6 for end stage renal disease.
• Patients with following codes in the any of the procedure codes will be excluded: L74.2 for arterio-venous fistula, L74.3 for arterio-venous graft.
• Patients', who were admitted in the study period, but were not discharged, will be excluded.

Sponsors & Collaborators

• University Hospitals of Derby and Burton NHS Foundation Trust: lead

Study Sites (1)

Derby Hospital NHS Foundation Trust

Derby, Derbyshire, DE22 3NE, United Kingdom

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Results Point of Contact

• Title: Nitin V Kolhe
• Organization: Derby Teaching Hospital NHS Trust

nitin.kolhe@nhs.net

01332788266

Study Officials

• Nitin V Kolhe, MD, DM

  Derby Hospital NHS Trust

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Nephrologist

Study Record Dates

• First Submitted: August 8, 2014
• First Posted: August 15, 2014
• Study Start: October 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: December 9, 2016
• Results First Posted: December 9, 2016

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)