Application of the Triple Stimulation Technique to Patients With CNS Disorders Including Stroke

NCT02354248 | Completed

• 1 other identifier: CHUB-TST01
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

TST (Triple stimulation technique) helps to better quantify the proportion of motor units activated by transcranial magnetic stimulation. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise with this technique than with the slowing of the central conduction time (CCT). The investigators propose to use this technique in CNS pathologies where this disorder is significant and essential, like multiple sclerosis and stroke.

Conditions

Stroke Patients

Keywords

TST; TMS; Stroke patients; EMG

Outcome Measures

Primary Outcomes (5)

• Amplitude of the motor evoked potentials

  during the TST (30 min)

• Surface of the motor evoked potentials

  during the TST (30 min)

• Amplitude ratio of the TST

  during the TST (30 min)

• Surface ratio of the TST

  during the TST (30 min)

• TMS threshold

  during TST (30 min)

Study Arms (2)

Stroke patients

EXPERIMENTAL

The patients will be submitted to a triple stimulation examination.

Procedure: Triple stimulation technique

Control Subjects

ACTIVE COMPARATOR

This group of patients did not suffer from a stroke. They will also be submitted to a triple stimulation examination.

Procedure: Triple stimulation technique

Interventions

Triple stimulation technique PROCEDURE

Evoked motor potentials obtained by magnetic transcranial stimulation are usually used, in standard practice, to evaluate the corticospinal tract. This procedure combines two techniques: the magnetic stimulation and the electroneuromyography. It is based on the double collision principle between the descending central stimulation (magnetic) and the ascending peripheric stimulation, hereby suppressing the issue of desynchronisation of evoked motor potentials. The Triple stimulation technique allows a better quantification of the proportion of motor units activated by the transcranial stimulation.

Control Subjects; Stroke patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• stroke patients with hemiparesia

You may not qualify if:

• pace maker
• epilepsia
• metallic neurosurgical implants

Sponsors & Collaborators

• Brugmann University Hospital: lead

Study Sites (1)

CHU Brugmann

Brussels, 1020, Belgium

Location

Related Publications (2)

• Magistris MR, Rosler KM, Truffert A, Myers JP. Transcranial stimulation excites virtually all motor neurons supplying the target muscle. A demonstration and a method improving the study of motor evoked potentials. Brain. 1998 Mar;121 ( Pt 3):437-50. doi: 10.1093/brain/121.3.437.

  PMID: 9549520 BACKGROUND

• Magistris MR, Rosler KM, Truffert A, Landis T, Hess CW. A clinical study of motor evoked potentials using a triple stimulation technique. Brain. 1999 Feb;122 ( Pt 2):265-79. doi: 10.1093/brain/122.2.265.

  PMID: 10071055 BACKGROUND

Study Officials

• Bernard Dachy, MD

  CHU Brugmann

  PRINCIPAL INVESTIGATOR

• Andrey Bragin, MD

  CHU Brugmann

  PRINCIPAL INVESTIGATOR

• Pedro Calderon, MD

  CHU Brugmann

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of clinic

Study Record Dates

• First Submitted: January 23, 2015
• First Posted: February 3, 2015
• Study Start: June 11, 2014
• Primary Completion: September 13, 2016
• Study Completion: September 13, 2016
• Last Updated: January 23, 2018

Record last verified: 2018-01

Locations

BE (1)