Cold Therapy in the Treatment of Exercise-induced Muscle Damage

NCT02341612 | Completed DMC

• 1 other identifier: CEP/FS-UnB 234/13
• Study Type: interventional
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

Subjects were randomly placed in five groups: (1) single exposure at 5°C in cold water immersion, (2) single exposure at 15°C in cold water immersion, (3) multiple exposures at 10°C in cold water immersion, (4) whole body cryotherapy (WBC) at 110°C and (5) passive recovery (control group). The single exposure groups performed cold water immersion immediately after exercise-induced muscle damage (EIMD) for 20 minutes. The multiple exposures group performed cold water immersion immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes. The WBC group remained in the cabin immediately after EIMD for 3 min. The control group was not exposed to treatment after the EIMD protocol. The subjects were asked to visit the laboratory on seven occasions. The first visit was the familiarization of the subjects with experimental procedures and their anthropometric assessment. One week after familiarization, on visit two, volunteers performed the exercise-induced muscle damage (EIMD) protocol and they were allocated to one of experimental groups. Indirect markers of muscle damage and inflammatory responses were evaluated at baseline (pre), immediately post, 24h, 48h, 72h, 96h, and 168h following the EIMD protocol by measuring anterior thigh muscle swelling, isometric knee extensors peak torque, knee extensors muscle soreness, countermovement vertical jump and blood sample analyzes.

Conditions

Cryotherapy Effect

Keywords

exercise-induced muscle damage; skeletal muscle injury recovery; cryotherapy; recovery of function; rehabilitation

Outcome Measures

Primary Outcomes (1)

• Change of knee extensors muscle maximal isometric voluntary contraction during 168h post exercise-induced muscle damage (EIMD), assessed using isokinetic dynamometer

  at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.

Secondary Outcomes (4)

• Change of the anterior thigh muscle swelling during 168h post EIMD, assessed using ultrasound device

  at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.

• Change of the knee extensors muscle soreness during 168h post EIMD, assessed using a Visual Analogue Scale

  at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.

• Change of inflammatory response (Tumor Necrosis Factor-α, interleukin-6, interleukin-10, interleukin-1β, interleukin-1ra) during 168h post EIMD, assessed by blood sample analyzes

  at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.

• Change on the performance of countermovement vertical jump during 168h post EIMD, assessed using a force plate

  at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.

Study Arms (5)

single exposure at 5°C in CWI

EXPERIMENTAL

The subjects of this group performed cold water immersion (CWI) immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.

Other: single exposure at 5°C in CWI

single exposure at 15°C in CWI

EXPERIMENTAL

The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.

Other: single exposure at 15°C in CWI

multiple exposures at 10°C in CWI

EXPERIMENTAL

The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.

Other: multiple exposures at 10°C in CWI

whole body criotherapy (WBC)

EXPERIMENTAL

The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.

Other: whole body cryotherapy (WBC)

passive recovery

EXPERIMENTAL

The control group was not exposed to treatment after the EIMD protocol.

Other: passive recovery

Interventions

single exposure at 5°C in CWI OTHER

The subjects of this group performed cold water immersion immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.

single exposure at 5°C in CWI

single exposure at 15°C in CWI OTHER

The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.

single exposure at 15°C in CWI

multiple exposures at 10°C in CWI OTHER

The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.

multiple exposures at 10°C in CWI

whole body cryotherapy (WBC) OTHER

The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.

whole body criotherapy (WBC)

passive recovery OTHER

The control group was exposed to treatment after the EIMD protocol.

passive recovery

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• A history of quadriceps muscle tear
• Neurological disease involving the lower limbs
• Current lower-limb musculoskeletal injury and thigh skinfold thickness \>20 mm..
• Participants with potential vascular problems which cold therapy is contraindicated (eg, diagnoses of diabetes or Raynaud's disease) were also excluded

Sponsors & Collaborators

• University of Brasilia: lead
• Conselho Nacional de Desenvolvimento Científico e Tecnológico: collaborator

Study Sites (1)

University of Brasília

Brasília, Federal District, 72220-900, Brazil

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Angelina Freitas Siqueira

Study Record Dates

• First Submitted: December 16, 2014
• First Posted: January 19, 2015
• Study Start: December 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2014
• Last Updated: January 19, 2015

Record last verified: 2015-01

Locations

BR (1)