Cooling Induces Motor Facilitation With Sympathetic Activation

NCT05832970 | Completed

• 1 other identifier: CIMFSA
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

Cryotherapy has beneficial effects such as motor facilitation, increase isometric force generation, and reduce spasticity. It is known that the muscle spindle has sympathetic innervation. Muscle spindle sensitivity increase with sympathetic activity. This research has three hypotheses: First, short-term cold application to the skin increases sympathetic activity. Second, there is an increase in muscle spindle sensitivity with increased sympathetic activity. Third, the effect of short-term cold on muscle spindle sensitivity continues until the skin temperature returns to normal. The purpose of this research is to test these hypotheses.

Conditions

Cryotherapy Effect

Keywords

muscle spindle; sympathetic outflow; motor facilitation

Outcome Measures

Primary Outcomes (3)

• Change from baseline in Heart rate

  Heart rate will be monitored with DII derivation electrocardiographic recording.Heart rate will be reported as beats per minute.

  Baseline (pre-cold pressor test) and 0, 3, 6, 9, 12, 15 minutes post-cold pressor test

• Change from baseline in Soleus H-reflex

  By stimulating the tibial nerve with an electrical current, the Soleus H-reflex will be obtained. Its peak to peak amplitude will be measured in microvolts.

  Baseline (pre-cold pressor test) and 0, 3, 6, 9, 12, 15 minutes post-cold pressor test

• Change from baseline in T-reflex

  Soleus T-reflex will be obtained by hitting the Achilles tendon with the electronic reflex hammer. Its peak to peak amplitude will be measured in microvolts.

  Baseline (pre-cold pressor test) and 0, 3, 6, 9, 12, 15 minutes post-cold pressor test

Secondary Outcomes (1)

• Skin temperature

  Baseline (pre-cold pressor test) and 0, 3, 6, 9, 12, 15 minutes post-cold pressor test

Study Arms (1)

Hand cooling

EXPERIMENTAL

Records will be taken for Baseline electromyography, Heart rate, H-reflex, and T-reflex measurements before, during, and at 0, 3, 6, 9, 12, and 15. minutes before applying 2-4 degrees Celsius cold to the back of the hand in this group.

Other: Brief skin cooling

Interventions

Brief skin cooling OTHER

Brief skin cooling will be applied to the hand using the cold-bath immersion

Hand cooling

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being healthy
• Being a young adult (20-45 years old)
• Volunteer

You may not qualify if:

• Scar, dermatitis, etc. in the skin tissue where the superficial electromyography electrode will be placed
• Upper extremity bone and joint disease, history of neuromuscular disease
• Heart disease, Hypertension
• Cold intolerance

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Medicine Rehabilitation Training & Research Hospital

Istanbul, 34173, Turkey (Türkiye)

Location

Study Officials

• ILHAN KARACAN, MD, Prof

  İstanbul Physical Therapy Rehabilitation Training & Research Hosptial

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 3, 2023
• First Posted: April 27, 2023
• Study Start: April 3, 2023
• Primary Completion: April 7, 2023
• Study Completion: April 8, 2023
• Last Updated: April 27, 2023

Record last verified: 2023-04

Locations

TU (1)