RV Function Evaluation Assessed by Strain and Validated by MRI

NCT02326701 | Unknown

• 1 other identifier: DG001-HMO-CTIL
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Echocardiographic assessment of right ventricular function is an important diagnostic tool, and is a challenge due to the unique structure and anatomy of the right ventricle. Lately a new technique has been developed and used for evaluating both the left and the right ventricle function. This technique, called two dimensional (2D) speckle tracking, is based on detecting speckles in the myocardial tissue and using them as acoustic markers. The movement of these speckles represents the movement of the tissue, and allows us to evaluate its function, contraction and relaxation, this by calculating the strain rate, which is the speed of the speckles, and the strain, which is the distance between them. In the last few years this technique has been used to evaluate the systolic function of the right ventricle in several pathological conditions, such as pulmonary hypertension, pulmonary embolism and amyloidosis. Nonetheless, so far there has been little data on the normal RV strain and strain rate values. In this study the investigators aim to validate two dimensional (2D) speckle tracking measurements of the RV function by comparing them to strain measurements by cardiac MRI. Each patient performing cardiac MRI for any indication will perform an echocardiography examination in addition, and strain analysis performed on the cardiac MRI will be compared with two dimensional speckle tracking analysis performed on the echocardiography.

Conditions

Right Ventricular Function

Outcome Measures

Primary Outcomes (1)

• Correlation of 2D Echo and Echo strain measurements versus MRI measurements

  RV dimensions, RV function, RV strain measurements compared to MRI measurements

  1 year

Secondary Outcomes (1)

• Rehospitalization

  2 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients performing MRI for any indication

You may qualify if:

• Age: More than 18

You may not qualify if:

• Age: Children
• Unconcious patients.

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Study Sites (1)

Hadassah Medical Organization

Jerusalem, 91120, Israel

Location

Central Study Contacts

Ronen Beeri, MD

CONTACT

00972508573400; rbeeri@hadassah.org.il

Dan Gilon, MD

CONTACT

00972507874011; dangi@ekmd.huji.ac.il

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 2, 2014
• First Posted: December 29, 2014
• Study Start: December 1, 2014
• Primary Completion: December 1, 2016
• Last Updated: December 29, 2014

Record last verified: 2014-10

Locations

IL (1)