Effects of Pulmonary Resection on Right Ventricular Function

NCT07042893 | Recruiting

• 1 other identifier: 2024 - 1160
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Lung resection is associated with high postoperative morbidity and mortality and leads to a significant long-term decrease in functional capacity, particularly due to cardiorespiratory complications. One of the contributing factors to this functional decline is the postoperative reduction in right ventricular function. Due to the anatomical proximity and interactions, right ventricular function is evaluated by echocardiography following lung resection. The pulmonary artery pressure (PAP)/tricuspid annular plane systolic excursion (TAPSE) ratio is a parameter that provides a more comprehensive assessment of right heart function by evaluating both right ventricular systolic function and pulmonary artery pressure. In this study, investigators aimed to evaluate changes in right heart function by performing preoperative and postoperative echocardiographic assessments in participants undergoing lung resection, focusing on PAP/TAPSE ratios.

Conditions

Pulmonary Resection; Right Ventricular Function; Echocardiography; Cardiothoracic Anesthesia

Keywords

pulmonary resection; right ventricular function; echocardiography; cardiothoracic anesthesia

Outcome Measures

Primary Outcomes (3)

• Echocardiographic Assessment: TAPSE/PAP Ratio

  Patients will be evaluated by echocardiography 24 hours before surgery and on the second postoperative day, and the TAPSE/PAP ratio will be recorded in mm/mmHg.

  24 hours preoperatively and on postoperative day 2

• Echocardiographic Assessment: Tricuspid Annular Plane Systolic Excursion (TAPSE)

  Patients will be evaluated by echocardiography 24 hours preoperatively and on postoperative day 2, and TAPSE will be recorded in millimeters (mm).

  24 hours preoperatively and on postoperative day 2

• Echocardiographic Assessment: Pulmonary Artery Pressure (PAP)

  Patients will be evaluated by echocardiography 24 hours before surgery and on the second postoperative day, and PAP will be recorded in millimeters of mercury (mmHg).

  24 hours preoperatively and on postoperative day 2

Study Arms (1)

Group 1

In this study, a single group (Group 1) will be defined, and patients scheduled for lung resection who agree to participate will be included.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18 to 80 years scheduled to undergo lung resection surgery.

You may qualify if:

• Adults aged 18 to 80 years
• ASA classification I-III
• Patients scheduled to undergo lung resection in thoracic surgery

You may not qualify if:

• Patients with arrhythmia
• Patients using antiarrhythmic drugs
• Patients with renal failure requiring hemodialysis
• Patients with a history of previous lung surgery
• Patients with valvular heart disease
• Patients with a history of angina pectoris or myocardial infarction within the past month
• Patients with FEV1/FVC ratio below 60%

Sponsors & Collaborators

• Çağrı Özdemir: lead

Study Sites (1)

Gazi University Faculty of Medicine, Ankara

Ankara, yenimahalle, 06500, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Çağrı Özdemir

CONTACT

+905544239196; cagriozdemir@gazi.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: asst. prof.

Study Record Dates

• First Submitted: June 20, 2025
• First Posted: June 29, 2025
• Study Start: April 1, 2025
• Primary Completion: August 31, 2025
• Study Completion: September 15, 2025
• Last Updated: July 3, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)