Genetic Analysis of Childhood Obesity
OSV
1 other identifier
observational
300
1 country
1
Brief Summary
Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2015
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 15, 2014
CompletedFirst Posted
Study publicly available on registry
December 29, 2014
CompletedStudy Start
First participant enrolled
January 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2021
CompletedMarch 3, 2020
March 1, 2020
5.9 years
December 15, 2014
March 2, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
To identify the number of mutations or genes involved in genetic causes of Child obesity
Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes
first day of enrollement
Secondary Outcomes (3)
To identify the number of mutations in the population
first day of enrollement
To identify the number of new mutations present in the children's DNA and absent from their parents' genomes
first day of enrollement
To determine number of phenotypes associated to the child obesity genotype
first day of enrollement
Study Arms (3)
Syndromic obesity
Identification of genetic causes of obesity
Familial obesity
Identification of genetic causes of obesity
Isolated obesity
Identification of genetic causes of obesity
Interventions
A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition
Eligibility Criteria
Three categories of obese children with their biological parents will be included (syndromic, familial, isolated obesity).
You may qualify if:
- BMI \> curve of IOTF 30 (International Obesity Task Force)
- Age: between 6 months old and 18 years old
- Child presenting syndromic, isolated or familial obesity.
You may not qualify if:
- Common obesity
- Impossibility for blood sampling
- Impossibility to receive information
- Participation refusal of one of the parents
- Refusal to sign the informed consent
- Neither Healthcare coverage nor insurance
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Lille Catholic Universitylead
- Institut Pasteur de Lillecollaborator
Study Sites (1)
Hôpital Saint Vincent de Paul
Lille, France
Biospecimen
Blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Louise Montagne
Groupement des Hôpitaux de l'Institut Catholique de Lille
- PRINCIPAL INVESTIGATOR
Philippe Froguel, MD, PhD
UMR CNRS 8199, Institut Pasteur de Lille
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 15, 2014
First Posted
December 29, 2014
Study Start
January 1, 2015
Primary Completion
December 1, 2020
Study Completion
June 1, 2021
Last Updated
March 3, 2020
Record last verified: 2020-03