Influence of Daylong Glycemia on Detraining Induced Metabolic Changes

NCT02321033 | Completed

• 1 other identifier: Lazysportsmen2014
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Aim of the study is to investigate the impact of glycemic index (provided as soft drinks) on changes in insulin sensitivity, metabolic flexibility, and arterial stiffness in response to detraining. The investigators hypothesize that low glycemic soft drinks decrease the detraining-induced impairment of insulin sensitivity, metabolic flexibility and arterial stiffness.

Conditions

Healthy

Keywords

glycemic index; inactivity; insulin sensitivity; metabolic flexibility; arterial stiffness; young men

Outcome Measures

Primary Outcomes (1)

• Influence of GI on inactivity-induced changes in insulin sensitivity as measured by an OGTT

  Influence of GI (glycemic index) on detraining-induced changes (difference between the end of high activity and low activity phases) in insulin sensitivity Insulin sensitivity is assessed by HOMA and Matsuda indices

  the difference between the end of each 1 week activity phase (day 7 vs. day 14, low vs. high physical activity) is compared between high GI and low GI intervention

Secondary Outcomes (1)

• Influence of GI on inactivity-induced changes in metabolic flexibility as measured by indirect calorimetry (RER, respiratory exchange ratio)

  the difference between the end of each 1 week activity phase (day 7 vs. day 14) is compared between high GI and low GI intervention

Other Outcomes (1)

• Influence of GI on inactivity-induced changes in parameters of arterial stiffness as measured by pulse wave velocity

  the difference between the end of each 1 week activity phase (day 7 vs. day 14) is compared between high GI and low GI intervention

Study Arms (2)

low glycemic index

EXPERIMENTAL

palatinose in soft drinks

Dietary Supplement: soft drinks

high glycemic index

EXPERIMENTAL

sucrose plus maltodextrin in soft drinks

Dietary Supplement: soft drinks

Interventions

soft drinks DIETARY_SUPPLEMENT

soft drinks with palatinose and maltodextrin

high glycemic index; low glycemic index

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• normal weight men,
• age 18-35 y,
• active life style,
• \> 300 min sports/week

You may not qualify if:

• food allergies,
• regular use of medication,
• smoking,
• chronic disease,
• vegan/vegetarian diet

Sponsors & Collaborators

• University of Hohenheim: lead

Study Sites (1)

Institute of Nutritional Medicine, University of Hohenheim

Stuttgart, 70599, Germany

Location

MeSH Terms

Conditions

Sedentary Behavior; Insulin Resistance

Interventions

Carbonated Beverages

Condition Hierarchy (Ancestors)

Behavior; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Anja Bosy-Westphal, Prof PhD

  University of Hohenheim, Stuttgart, Germany

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2014
• First Posted: December 22, 2014
• Study Start: August 1, 2014
• Primary Completion: June 1, 2015
• Study Completion: September 1, 2015
• Last Updated: November 18, 2015

Record last verified: 2015-11

Locations

DE (1)