Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

NCT02320136 | Unknown

• 1 other identifier: HFO
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation. The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Conditions

Epilepsy; Tumor

Outcome Measures

Primary Outcomes (1)

• HFO (high-frequency oscillations) occurrence

  1 week

Study Arms (3)

epilepsy

epilepsy patients

Behavioral: cognitive testing

tumor with epilepsy

tumor patients with epileptic seizures

Behavioral: cognitive testing

tumor without epilepsy

tumor patients without epileptic seizures

Behavioral: cognitive testing

Interventions

cognitive testing BEHAVIORAL

patients perform simple tasks like watching a video or memorizing items

epilepsy; tumor with epilepsy; tumor without epilepsy

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Patients with epilepsy where a surgical resection is considered. 2. Patients where a tumor will be resected that has caused preoperative seizures. 3. Patients where a tumor will be resected that has not caused preoperative seizures.

You may qualify if:

• Patients intend to be treated at the Klinik für Neurochirurgie
• Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery. (2)Patients where a tumor is planned to be resected that has caused preoperative seizures. (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.
• Male and Female subjects 18 years to 99 years of age
• Written informed consent after participants' information

You may not qualify if:

• contraindications on ethical grounds
• known or suspected non-compliance, drug or alcohol abuse,
• enrolment into a clinical trial within last 4 weeks

Sponsors & Collaborators

• University of Zurich: lead

MeSH Terms

Conditions

Epilepsy; Neoplasms

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Johannes Sarnthein, Prof Dr

  Universitätsspital Zürich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2014
• First Posted: December 19, 2014
• Study Start: June 1, 2014
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2025
• Last Updated: December 1, 2023

Record last verified: 2023-11