Pilot Testing a New Computer-based Screening Tool to Detect Cognitive Impairment

NCT01220674 | Completed

• 1 other identifier: 0491-10-FB
• Study Type: observational
• Target: 152
• Locations: 1 country
• Sites: 1

Brief Summary

A computer-based neuropsychological assessment tool is being developed to help primary care physicians detect neurological and psychiatric disorders. The first version will be tested against current tests to confirm the tool's effectiveness. Data will be collected on how well the tool detects disease, how well patients understand the instructions and enjoy performing the tasks, and if particular trials or stimuli are too difficult or too easy for all subjects. Adjustments can then be made to the assessment tool, if needed. The initial participants will be age fifty-five to seventy-five with early dementias or mild cognitive impairment to reduce variability.

Conditions

Cognitive Impairment

Keywords

neuropsychological assessment; cognitive impairment; computer-aided diagnostic tool

Study Arms (2)

community dwelling older adults, normal controls

men and women 55 years of age or older who are cognitively intact.

Other: cognitive testing

community dwelling older adults, mild cognitive impairment

men and women 55 years of age or older who have minimal cognitive decline (MMSE 20-24).

Other: cognitive testing

Interventions

cognitive testing OTHER

computer-based cognitive assessment

community dwelling older adults, mild cognitive impairment; community dwelling older adults, normal controls

Eligibility Criteria

• Age: 55 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Community-dwelling adults without significant cognitive impairment

You may qualify if:

• Any subject with mild impairment from who has already undergone or will soon undergo a full neuropsychological evaluation.
• Subjects with Clinical Dementia Rating Scale CDR of 0.5-1.0 and Mini-Mental Score 20-26 (or MOCA equivalent, borderline/mild dementia) will be eligible for this group.

You may not qualify if:

• Subjects whose impairment is severe enough to limit their ability to perform the computer-based tasks and/or to provide consent.
• Subjects with history of learning disabilities or mental illness including major depression, bipolar disorder, anxiety disorders, and addiction are excluded because these problems can affect cognitive performance.

Sponsors & Collaborators

• University of Nebraska: lead
• Massachusetts Institute of Technology: collaborator
• San Mateo Medical Center: collaborator
• VA Northern California Health Care System: collaborator

Study Sites (1)

Unversity of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Stephen J Bonasera, MD, PhD

  University of Nebraska

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 12, 2010
• First Posted: October 14, 2010
• Study Start: December 15, 2010
• Primary Completion: October 31, 2012
• Study Completion: October 31, 2012
• Last Updated: September 14, 2023

Record last verified: 2023-09

Locations

US (1)