The Effects of Obesity on 8-Hydroxy-Deoxyguanosine Levels in Patients With and Without Periodontal Disease

NCT02316093 | Completed

• 1 other identifier: 20136255051502
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Obesity may affect periodontal health by inducing gingival oxidative damage through increased production in circulating reactive oxygen species (ROS). Several studies have demonstrated that 8-OHdG in bodily fluids can act as a biomarker of oxidative DNA damage in periodontal diseases and for evaluating the effect of periodontal treatment. In the present study we hypothesized that high ROS levels in circulation may increase oxidative stress levels in the gingival crevicular fluid (GCF) and saliva in obese patients with periodontal disease, thus periodontal therapy could have positive effects on ROS levels.

Conditions

Obesity

Outcome Measures

Primary Outcomes (2)

• plasma, saliva and GCF levels of 8-OHdG

  baseline

• plasma, saliva and GCF levels of 8-OHdG

  a month after periodontal treatment

Study Arms (6)

obese-chronic periodontitis patients

Other: Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling

obese-gingivitis patients

Other: Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling

obese-periodontally healthy controls

Other: Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling

normal weight-chronic periodontitis patients

Other: Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling

normal weight-gingivitis patients

Other: Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling

normal weight-periodontally healthy controls

Other: Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling

Interventions

Procedure: Gingival Crevicular Fluid, Saliva and Blood Sampling OTHER

normal weight-chronic periodontitis patients; normal weight-gingivitis patients; normal weight-periodontally healthy controls; obese-chronic periodontitis patients; obese-gingivitis patients; obese-periodontally healthy controls

Eligibility Criteria

• Age: 25 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

a population who received periodontal treatment at the Periodontology Department

You may qualify if:

• never-smokers
• no history of systemic disease
• no patients had been under periodontal treatment and medicine for at least 6 months before the study
• no pregnancy or lactation
• no alcohol or antioxidant vitamin consumption.

Sponsors & Collaborators

• Bulent Ecevit University: lead

MeSH Terms

Conditions

Obesity

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Faculty of Dentistry

Study Record Dates

• First Submitted: December 10, 2014
• First Posted: December 12, 2014
• Study Start: March 1, 2013
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: December 12, 2014

Record last verified: 2014-12