Cardiovascular Health Improvement Project

NCT02306200 | Recruiting DMC

• 1 other identifier: HUM00052866
• Study Type: observational
• Target: 15,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.

Conditions

Bicuspid Aortic Valve (BAV); Heart Failure; Cardiovascular Diseases; Aortic Aneurysm; Aortic Dissection

Keywords

Aorta; Abdominal Aortic Aneurysm (AAA); Thoracic Aortic Aneurysm (TAA); Bicuspid Aortic Valve (BAV); Aortic Dissection

Outcome Measures

Primary Outcomes (1)

• Establishing a biobank of patients with Aortic Disease

  Establish a biobank of blood, serum, plasma, tissue, and clinical data of patients with any form of aortic disease

  40 years

Study Arms (2)

Aortic Disease

Patients with a diagnosis of any form of Aortic Disease

Controls

Patients without a diagnosis of Aortic Disease

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Outpatient clinic

You may qualify if:

• Any patient over the age of 18 who is able/willing to give informed consent
• Patients \<18 years of age with parental consent and assent (if assent is applicable for their age)
• Diagnosis of:
• aortic pathology potentially due to a known or suspected inherited condition
• Idiopathic aortic aneurysm
• Interesting of novel vascular pathology in the aorta or main branches
• Family history of aortic or vascular disease
• Other cardiovascular disease
• Healthy controls with no apparent cardiovascular disease

You may not qualify if:

• \- Not willing or able to sign the consent

Sponsors & Collaborators

• University of Michigan: lead

Study Sites (1)

University of Michigan

Ann Arbor, Michigan, 48109, United States

RECRUITING

Related Publications (1)

• Love-Nichols J, Uhlmann WR, Arscott P, Willer C, Hornsby W, Roberts JS. A survey of aortic disease biorepository participants' preferences for return of research genetic results. J Genet Couns. 2021 Jun;30(3):645-655. doi: 10.1002/jgc4.1341. Epub 2020 Dec 14.

  PMID: 33319384 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood, Tissue

MeSH Terms

Conditions

Aortic Aneurysm; Aortic Dissection; Bicuspid Aortic Valve Disease; Heart Failure; Cardiovascular Diseases; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic

Condition Hierarchy (Ancestors)

Aneurysm; Vascular Diseases; Aortic Diseases; Dissection, Blood Vessel; Acute Aortic Syndrome; Heart Defects, Congenital; Cardiovascular Abnormalities; Heart Diseases; Aortic Valve Disease; Heart Valve Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Marion A Hofmann Bowman, PhD, MD

  University of Michigan

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lauren Humphrey-Stark, BS

CONTACT

7342324779; ljeany@med.umich.edu

Jen McNamara, MS

CONTACT

734-232-6180; jlmcnama@med.umich.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 40 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Internal Medicine

Study Record Dates

• First Submitted: December 1, 2014
• First Posted: December 3, 2014
• Study Start: August 1, 2013
• Primary Completion (Estimated): August 1, 2053
• Study Completion (Estimated): August 1, 2053
• Last Updated: April 29, 2026

Record last verified: 2026-04

Locations

US (1)