NCT02301624

Brief Summary

To evaluate the safety and efficacy of eculizumab in the treatment of refractory generalized myasthenia gravis (gMG) as an extension study for the participants who previously completed Study ECU-MG-301(NCT01997229).

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
117

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Nov 2014

Typical duration for phase_3

Geographic Reach
17 countries

60 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 12, 2014

Completed
10 days until next milestone

First Submitted

Initial submission to the registry

November 22, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 26, 2014

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 15, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 15, 2019

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

February 5, 2020

Completed
Last Updated

February 5, 2020

Status Verified

January 1, 2020

Enrollment Period

4.2 years

First QC Date

November 22, 2014

Results QC Date

December 9, 2019

Last Update Submit

January 27, 2020

Conditions

Keywords

gMGMyasthenia Gravissafetyefficacy

Outcome Measures

Primary Outcomes (1)

  • Count Of Participants With Treatment-Emergent Adverse Events

    Treatment-emergent adverse events (TEAEs) are adverse events with onset on or after the first study drug dose in Study ECU-MG-302. Likewise, treatment-emergent serious adverse events (TESAEs) are serious adverse events that onset on or after the first study drug dose in Study ECU-MG-302. A summary of serious and all other non-serious adverse events, regardless of causality, is located in the Reported Adverse Events module.

    Day 1 (after dosing) through End of Study (Week 208)

Secondary Outcomes (1)

  • Change From Baseline In Myasthenia Gravis Activities Of Daily Living Profile (MG-ADL) Total Score At Week 4 And Week 130

    Baseline, Week 4 and Week 130

Study Arms (2)

Eculizumab/Eculizumab

EXPERIMENTAL

Blind Induction Phase: Participants who had received blinded treatment with eculizumab in Study ECU-MG-301 were administered eculizumab (4 vials/1200 milligrams \[mg\]) on Day 1 and Week 2 and placebo (4 vials/0 mg) at Weeks 1 and 3. Open-Label Maintenance Phase: Participants received open-label eculizumab (4 vials/1200 mg) every 2 weeks starting at Week 4 and continued throughout the study. Eculizumab 1200 mg was administered for up to 4 years in this extension study.

Biological: EculizumabDrug: Placebo

Placebo/Eculizumab

EXPERIMENTAL

Blind Induction Phase: Participants who had received blinded treatment with placebo in Study ECU-MG-301 were administered eculizumab/placebo (3 vials/900 mg, plus 1 vial/0 mg, respectively) on Day 1 and Weeks 1 through 3. Open-Label Maintenance Phase: Participants received open-label eculizumab (4 vials/1200 mg) every 2 weeks starting at Week 4 and continued throughout the study. Eculizumab 1200 mg was administered for up to 4 years in this extension study.

Biological: EculizumabDrug: Placebo

Interventions

EculizumabBIOLOGICAL

Intravenous administration of eculizumab.

Eculizumab/EculizumabPlacebo/Eculizumab

Intravenous administration of matching placebo. Participants received placebo only during the Blind Induction Phase.

Eculizumab/EculizumabPlacebo/Eculizumab

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participant has completed Study ECU-MG-301.
  • Participant has given written informed consent.
  • Participant was willing and able to comply with the protocol requirements for the duration of the study.
  • Female participant of childbearing potential must have had a negative pregnancy test (serum human chorionic gonadotropin). All participants were required to practice an effective, reliable, and medically approved contraceptive regimen during the study and for up to 5 months following discontinuation of treatment.

You may not qualify if:

  • Participants who withdrew from Study ECU-MG-301 as a result of an adverse event related to study drug.
  • Female participants who were pregnant, breastfeeding, or intended to conceive during the course of the study.
  • Unresolved meningococcal infection
  • Hypersensitivity to murine proteins or to one of the excipients of eculizumab
  • Any medical condition or circumstances that, in the opinion of the investigator, might have interfered with the participant's participation in the study, posed any added risk for the participant, or confounded the assessment of the participants.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (60)

Unknown Facility

Birmingham, Alabama, 35233, United States

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Los Angeles, California, 90033, United States

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Orange, California, 92868, United States

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Palo Alto, California, 94304, United States

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San Francisco, California, 94115, United States

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New Haven, Connecticut, 06519, United States

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Jacksonville, Florida, 32209, United States

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Miami, Florida, 33136, United States

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Tampa, Florida, 33612, United States

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Springfield, Illinois, 62702, United States

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Indianapolis, Indiana, 46202, United States

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Iowa City, Iowa, 52242, United States

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Kansas City, Kansas, 66160, United States

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Baltimore, Maryland, 21201-1595, United States

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Baltimore, Maryland, 21287-0876, United States

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Boston, Massachusetts, 02115, United States

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Burlington, Massachusetts, 01805, United States

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Las Vegas, Nevada, 89145, United States

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Chapel Hill, North Carolina, 27599, United States

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Charlotte, North Carolina, 28207, United States

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Durham, North Carolina, 27710, United States

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Columbus, Ohio, 43210, United States

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Portland, Oregon, 97239, United States

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San Antonio, Texas, 78229, United States

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Burlington, Vermont, 05401, United States

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Seattle, Washington, 98195, United States

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Buenos Aires, Argentina

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Edegem, Belgium

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Ghent, Belgium

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Leuven, Belgium

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São Paulo, Brazil

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Edmonton, Canada

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Ostrava - Poruba, Czechia

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Prague, Czechia

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Arhus C, Denmark

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Copenhagen, Denmark

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Turku, Finland

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Szeged, Hungary

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Milan, Italy

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Napoli, Italy

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Roma, Italy

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Chiba, Japan

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Fukuoka, Japan

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Hanamaki, Japan

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Hokkaido, Japan

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Miyagi, Japan

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Nagasaki, Japan

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Osaka, Japan

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Osaka-Fu, Japan

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Amsterdam, Netherlands

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Seoul, South Korea

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Barcelona, Spain

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Madrid, Spain

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Stockholm, Sweden

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Ankara, Turkey (Türkiye)

Location

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Izmir, Turkey (Türkiye)

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Kocaeli, Turkey (Türkiye)

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Birmingham, United Kingdom

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Liverpool, United Kingdom

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Unknown Facility

London, United Kingdom

Location

Related Publications (11)

  • Muppidi S, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Nowak RJ, Andersen H, Casasnovas C, de Bleecker JL, Vu TH, Mantegazza R, O'Brien FL, Wang JJ, Fujita KP, Howard JF Jr; Regain Study Group. Long-term safety and efficacy of eculizumab in generalized myasthenia gravis. Muscle Nerve. 2019 Jul;60(1):14-24. doi: 10.1002/mus.26447. Epub 2019 Mar 8.

  • Andersen H, Mantegazza R, Wang JJ, O'Brien F, Patra K, Howard JF Jr; REGAIN Study Group. Correction to: Eculizumab improves fatigue in refractory generalized myasthenia gravis. Qual Life Res. 2019 Aug;28(8):2255. doi: 10.1007/s11136-019-02204-x.

  • Andersen H, Mantegazza R, Wang JJ, O'Brien F, Patra K, Howard JF Jr; REGAIN Study Group. Eculizumab improves fatigue in refractory generalized myasthenia gravis. Qual Life Res. 2019 Aug;28(8):2247-2254. doi: 10.1007/s11136-019-02148-2. Epub 2019 Mar 23.

  • Murai H, Uzawa A, Suzuki Y, Imai T, Shiraishi H, Suzuki H, Okumura M, O'Brien F, Wang JJ, Fujita KP, Utsugisawa K; REGAIN Study Group. Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study. J Neurol Sci. 2019 Dec 15;407:116419. doi: 10.1016/j.jns.2019.08.004. Epub 2019 Aug 3.

  • Siddiqi ZA, Nowak RJ, Mozaffar T, O'Brien F, Yountz M, Patti F; REGAIN Study Group. Eculizumab in refractory generalized myasthenia gravis previously treated with rituximab: subgroup analysis of REGAIN and its extension study. Muscle Nerve. 2021 Dec;64(6):662-669. doi: 10.1002/mus.27422. Epub 2021 Oct 14.

  • Murai H, Suzuki S, Hasebe M, Fukamizu Y, Rodrigues E, Utsugisawa K. Safety and effectiveness of eculizumab in Japanese patients with generalized myasthenia gravis: interim analysis of post-marketing surveillance. Ther Adv Neurol Disord. 2021 Mar 16;14:17562864211001995. doi: 10.1177/17562864211001995. eCollection 2021.

  • Nowak RJ, Muppidi S, Beydoun SR, O'Brien FL, Yountz M, Howard JF Jr. Concomitant Immunosuppressive Therapy Use in Eculizumab-Treated Adults With Generalized Myasthenia Gravis During the REGAIN Open-Label Extension Study. Front Neurol. 2020 Nov 24;11:556104. doi: 10.3389/fneur.2020.556104. eCollection 2020.

  • Mantegazza R, Wolfe GI, Muppidi S, Wiendl H, Fujita KP, O'Brien FL, Booth HDE, Howard JF Jr; REGAIN Study Group. Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension. Neurology. 2021 Jan 26;96(4):e610-e618. doi: 10.1212/WNL.0000000000011207. Epub 2020 Nov 23.

  • Mantegazza R, O'Brien FL, Yountz M, Howard JF Jr; REGAIN study group. Consistent improvement with eculizumab across muscle groups in myasthenia gravis. Ann Clin Transl Neurol. 2020 Aug;7(8):1327-1339. doi: 10.1002/acn3.51121. Epub 2020 Jul 22.

  • Jacob S, Murai H, Utsugisawa K, Nowak RJ, Wiendl H, Fujita KP, O'Brien F, Howard JF Jr. Response to eculizumab in patients with myasthenia gravis recently treated with chronic IVIg: a subgroup analysis of REGAIN and its open-label extension study. Ther Adv Neurol Disord. 2020 May 6;13:1756286420911784. doi: 10.1177/1756286420911784. eCollection 2020.

  • Vissing J, Jacob S, Fujita KP, O'Brien F, Howard JF; REGAIN study group. 'Minimal symptom expression' in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab. J Neurol. 2020 Jul;267(7):1991-2001. doi: 10.1007/s00415-020-09770-y. Epub 2020 Mar 18.

MeSH Terms

Conditions

Myasthenia Gravis

Interventions

eculizumab

Condition Hierarchy (Ancestors)

Paraneoplastic Syndromes, Nervous SystemNervous System NeoplasmsNeoplasms by SiteNeoplasmsParaneoplastic SyndromesAutoimmune Diseases of the Nervous SystemNervous System DiseasesNeurodegenerative DiseasesNeuromuscular Junction DiseasesNeuromuscular DiseasesAutoimmune DiseasesImmune System Diseases

Results Point of Contact

Title
Alexion Pharmaceuticals Inc.
Organization
Alexion Pharmaceuticals Inc.

Study Officials

  • Marcus Yountz, MD

    Alexion Pharmaceuticals, Inc.

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NON RANDOMIZED
Masking
NONE
Masking Details
The study consisted of a 4-week Blind Induction Phase to preserve the blinded nature of Study ECU-MG-301, followed by an Open-Label Maintenance Phase.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Following the Blind Induction Phase, all participants received open-label eculizumab.
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 22, 2014

First Posted

November 26, 2014

Study Start

November 12, 2014

Primary Completion

January 15, 2019

Study Completion

January 15, 2019

Last Updated

February 5, 2020

Results First Posted

February 5, 2020

Record last verified: 2020-01

Locations