Success Metrics

Clinical Success Rate
79.7%

Based on 55 completed trials

Completion Rate
80%(55/69)
Active Trials
4(5%)
Results Posted
84%(46 trials)
Terminated
14(17%)

Phase Distribution

Ph phase_1
11
13%
Ph early_phase_1
1
1%
Ph phase_2
35
42%
Ph phase_3
28
33%
Ph phase_4
3
4%

Phase Distribution

12

Early Stage

35

Mid Stage

31

Late Stage

Phase Distribution78 total trials
Early Phase 1First-in-human
1(1.3%)
Phase 1Safety & dosage
11(14.1%)
Phase 2Efficacy & side effects
35(44.9%)
Phase 3Large-scale testing
28(35.9%)
Phase 4Post-market surveillance
3(3.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.4%

55 of 72 finished

Non-Completion Rate

23.6%

17 ended early

Currently Active

4

trials recruiting

Total Trials

84

all time

Status Distribution
Active(5)
Completed(55)
Terminated(17)
Other(7)

Detailed Status

Completed55
Terminated14
unknown7
Active, not recruiting4
Withdrawn3
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
84
Active
4
Success Rate
79.7%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.3%)
Phase 111 (14.1%)
Phase 235 (44.9%)
Phase 328 (35.9%)
Phase 43 (3.8%)

Trials by Status

active_not_recruiting45%
unknown78%
completed5565%
withdrawn34%
terminated1417%
not_yet_recruiting11%

Recent Activity

Clinical Trials (84)

Showing 20 of 84 trialsScroll for more
NCT02205541Phase 3

Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU

Completed
NCT04935177Phase 3

Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx

Completed
NCT05133531Phase 3

A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment

Active Not Recruiting
NCT04432584Phase 3

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Active Not Recruiting
NCT04434092Phase 3

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

Active Not Recruiting
NCT06764160Phase 3

Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Eculizumab in Chinese Adults With gMG

Completed
NCT06724809Phase 3

Efficacy, Safety, PK, PD, and ADA of Eculizumab in Chinese Adults With NMOSD

Active Not Recruiting
NCT05876351Phase 3

Eculizumab in Pediatric and Adult Participants With Atypical Hemolytic Uremic Syndrome (aHUS) in China

Completed
NCT06513338Phase 2

Complement C5 mAb in the Treatment of Anti-GBM Disease

Completed
NCT02113891Phase 1

Eculizumab Therapy for Subclinical Antibody-mediated Rejection in Kidney Transplantation

Withdrawn
NCT04752566Phase 3

A Study to Evaluate the Efficacy and Safety of Eculizumab in Guillain-Barré Syndrome

Completed
NCT06987864Phase 3

An Extension Clinical Study of BCD-148 for the Treatment of Patients With PNH Previously Treated in Clinical Study No. BCD-148-2/NOCTURN

Completed
NCT05886244Phase 3

Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) in China

Completed
NCT04702568Phase 2

A Long-Term Safety Study of BCX9930 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Terminated
NCT05131204Phase 3

Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria

Terminated
NCT03056040Phase 3

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Completed
NCT05116774Phase 2

BCX9930 for the Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) in Participants With Inadequate Response to C5 Inhibitor Therapy

Terminated
NCT03759366Phase 3

A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG)

Completed
NCT04558918Phase 3

Study of Efficacy and Safety of Twice Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite Anti-C5 Antibody Treatment

Completed
NCT04155424Phase 2

A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
84