Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
1 other identifier
interventional
17
0 countries
N/A
Brief Summary
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2014
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2014
CompletedFirst Submitted
Initial submission to the registry
October 29, 2014
CompletedFirst Posted
Study publicly available on registry
October 31, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2016
CompletedResults Posted
Study results publicly available
February 7, 2018
CompletedFebruary 7, 2018
February 1, 2018
2.3 years
October 29, 2014
October 24, 2017
February 5, 2018
Conditions
Outcome Measures
Primary Outcomes (2)
Cardiac Function: Duration of Apnea
Alteration of cardiac function in subjects undergoing maximum apnea.
every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements
Mean Blood Flow Measurement Under Apnea Using MRI
Blood flow pattern in subjects undergoing maximum apnea.
Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements
Study Arms (1)
Deliberate Apnea Group
EXPERIMENTALSubjects undergo maximum apnea.
Interventions
Eligibility Criteria
You may qualify if:
- Being able to hold breath deliberately at least 4,5 minutes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Eichhorn L, Doerner J, Luetkens JA, Lunkenheimer JM, Dolscheid-Pommerich RC, Erdfelder F, Fimmers R, Nadal J, Stoffel-Wagner B, Schild HH, Hoeft A, Zur B, Naehle CP. Cardiovascular magnetic resonance assessment of acute cardiovascular effects of voluntary apnoea in elite divers. J Cardiovasc Magn Reson. 2018 Jun 18;20(1):40. doi: 10.1186/s12968-018-0455-x.
PMID: 29909774DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Jonas Doerner
- Organization
- University of Bonn
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
October 29, 2014
First Posted
October 31, 2014
Study Start
April 1, 2014
Primary Completion
July 1, 2016
Study Completion
July 1, 2016
Last Updated
February 7, 2018
Results First Posted
February 7, 2018
Record last verified: 2018-02