Cardiac Magnetic Resonance Imaging and Pulmonary Perfusion

NCT01100008 | Completed

• 1 other identifier: 06 042 02
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary hypertension is a rare severe disease leading to cardiac insufficiency. Treatment depends on the severity of the disease. This study evaluates cardiac MRI for the assessment of pulmonary hypertension severity and identification of parameters useful for the follow-up in order to adapt the medical treatment to status of the patient. Evaluate if cardiac MRI can obviate right cardiac catheterization in the follow-up.

Conditions

Pulmonary Hypertension

Keywords

Pulmonary arterial hypertension; cardiac MRI (magnetic resonance imaging); severity; prognosis

Outcome Measures

Primary Outcomes (1)

• Nuclear magnetic resonance imaging

  Correlation of cardiac results from the first MRI (Magnetic Resonance Imaging) to invasive measurements from the first or initial right heart catheterization and to echocardiography to know if cardiac MRI is able to predict severity of the disease

  Inclusion ; 3rd month ; 12th month

Study Arms (1)

Magnetic resonance imaging

EXPERIMENTAL

Procedure: Magnetic resonance imaging (MRI)

Interventions

Magnetic resonance imaging (MRI) PROCEDURE

MRI cardiac and pulmonary with gadolinium

Magnetic resonance imaging

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Etiologies include chronic embolic disease, systemic fibrosis, Gougerot Sjogren, drug induced hypertension, primary hypertension.
• informed consent
• affiliated to medical insurance.

You may not qualify if:

• Left cardiac disease responsible for pulmonary hypertension, congenital cardiopathies
• Pulmonary functional tests with important impairment (decrease in TPCmore than 30%, decrease In VEMS more than 30%
• Child
• pregnancy
• contraindications to MRI
• without informed consent
• without insurance

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

Service de radiologie - Hôpital Rangueil

Toulouse, Midi-Pyrénées, 31000, France

Location

MeSH Terms

Conditions

Hypertension, Pulmonary; Pulmonary Arterial Hypertension

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Valérie Chabbert, MD

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 1, 2010
• First Posted: April 8, 2010
• Study Start: September 1, 2007
• Primary Completion: September 1, 2013
• Study Completion: June 1, 2014
• Last Updated: March 14, 2016

Record last verified: 2016-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)