TMS in Borderline Personality Disorder Patients
Repetitive Transcranial Magnetic Stimulation in Borderline Personality Disorder Patients. Effects in Clinical Measurements, Inhibition, Cognitive Flexibility, and Social Cognition Process
1 other identifier
interventional
40
1 country
1
Brief Summary
The purpose of this study is to determine the potential effects of repetitive transcranial magnetic stimulation in the improvement of neuropsychological deficits and symptomatology in borderline personality disorder patients. Specially in cognitive flexibility, inhibition control and social cognition.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2014
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2014
CompletedFirst Submitted
Initial submission to the registry
October 15, 2014
CompletedFirst Posted
Study publicly available on registry
October 24, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2016
CompletedFebruary 23, 2016
February 1, 2016
2 years
October 15, 2014
February 22, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change from Baseline in BORDERLINE EVALUATION OF SEVERITY OVER TIME (BEST)
The Borderline Evaluation of Severity Over Time (BEST) was developed to rate the thoughts, emotions, and behaviors typical of borderline personality disorder.
Inclusion, after 15 days of treatment and at 8 weeks follow up
Secondary Outcomes (5)
Change from Baseline in Barratt impulsiveness scale
IInclusion, after 15 days of treatment and at 8 weeks follow up
Change from Baseline in Hamilton Depression rating scale
Inclusion, after 15 days of treatment and at 8 weeks follow up
Change from Baseline in Wisconsin card sorting test (WCST)
Inclusion, after 15 days of treatment and at 8 weeks follow up
Change from Baseline in Stop Signal Task (SST)
Inclusion, after 15 days of treatment and at 8 weeks follow up
Change from Baseline in Reading the Mind in the Eyes Test
Inclusion, after 15 days of treatment and at 8 weeks follow up
Study Arms (2)
Left rTMS 5 Hz
EXPERIMENTALThis group receive transcranial magnetic stimulation at 5 Hz of frequency over left dorsolateral prefrontal cortex. Once a day on monday to friday. Until receive 15 sessions. After this the subjects, will be received 8 more sessions of TMS, one session at week for next eight weeks
Right r TMS 1 Hz
EXPERIMENTALThis group receive transcranial magnetic stimulation at 1 Hz of frequency over right dorsolateral prefrontal cortex. Once a day on monday to friday. Until receive 15 sessions. After this the subjects, will be received 8 more sessions of TMS, one session at week for next eight weeks
Interventions
The subjects will receive transcranial magnetic stimulation (5 Hz of frequency over left dorsolateral prefrontal cortex . Once a day on monday to friday. Until receive 15 sessions. After this the subjects, will be received 8 more sessions of TMS, one session at week for next eight weeks
The subjects will receive transcranial magnetic stimulation (1 Hz of frequency over right dorsolateral prefrontal cortex . Once a day on monday to friday. Until receive 15 sessions. After this the subjects, will be received 8 more sessions of TMS, one session at week for next eight weeks
Eligibility Criteria
You may qualify if:
- Diagnosis of borderline personality disorder according to diagnostic and statistical manual of mental disorders IV text revision
- Treatment with selective inhibitors of serotonin reuptake
- Mass corporal index more than 19
You may not qualify if:
- Suicide risk or suicide attempt recent or actual
- History of epilepsy or seizures
- History of cranial trauma with loss awareness
- Intracranial or intraocular ferromagnetic devices, including skull prosthesis.
- Pregnant womens.
- Neurosurgery, cardiac pacemaker, lefthander
- Patients with psychotic symptoms, bipolar disorder or substance addiction.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Instituto Nacional de Psiquiatria Ramon de la Fuente
Mexico City, Mexico City, 14370, Mexico
Related Publications (2)
Arbabi M, Hafizi S, Ansari S, Oghabian MA, Hasani N. High frequency TMS for the management of Borderline Personality Disorder: a case report. Asian J Psychiatr. 2013 Dec;6(6):614-7. doi: 10.1016/j.ajp.2013.05.006. Epub 2013 Jun 14.
PMID: 24309885BACKGROUNDReyes-Lopez J, Ricardo-Garcell J, Armas-Castaneda G, Garcia-Anaya M, Arango-De Montis I, Gonzalez-Olvera JJ, Pellicer F. Clinical improvement in patients with borderline personality disorder after treatment with repetitive transcranial magnetic stimulation: preliminary results. Braz J Psychiatry. 2018 Jan-Mar;40(1):97-104. doi: 10.1590/1516-4446-2016-2112. Epub 2017 Jun 12.
PMID: 28614492DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Julian V Reyes, M.D.
Instituto Nacional de Psiquiatria
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Medical doctor Psychiatry
Study Record Dates
First Submitted
October 15, 2014
First Posted
October 24, 2014
Study Start
January 1, 2014
Primary Completion
January 1, 2016
Study Completion
February 1, 2016
Last Updated
February 23, 2016
Record last verified: 2016-02