Central Meditation and Imagery Therapy for Augmentation of Borderline Personality Disorder Treatment

NCT02125942 | Completed

• 1 other identifier: CMIT1044
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Borderline personality disorder is a severe psychiatric disorder marked by emotional instability, difficulty with interpersonal relationships, and self-harming behaviors. Despite receiving psychotherapy for borderline personality disorder, studies show that patient recovery is slow, and there is a high rate of self injury and suicide attempts early in treatment. There is thus a clear need to provide therapies to augment psychotherapy. We will conduct a pilot trial to determine whether a 6-week Central Meditation and Imagery Therapy (CMIT) is feasible for subjects with borderline personality disorder to undergo when added on to psychotherapy treatment. CMIT is a non-validated therapy that combines principles of mindfulness with meditation techniques and guided imagery. Sessions led by a trained clinician in a group setting once a week, and participants are asked to complete daily home practice. The trial will involve 16 participants, all currently undergoing psychotherapy for borderline personality disorder. Participants will be randomly assigned to either a CMIT group that lasts 6 weeks, or a wait list group. Those in the wait list group will be able to receive CMIT after 6 weeks. All participants will continue to receive psychotherapy throughout the trial. During the trial, we will also obtain preliminary data to help understand whether CMIT may result in psychological benefits for participants. This will include measuring the pulse in order to determine variation in beat to beat intervals of the heart during psychological tests, and filling out questionnaires before and after participation in CMIT.

Conditions

Borderline Personality Disorder

Keywords

Borderline Personality Disorder

Outcome Measures

Primary Outcomes (1)

• Borderline Symptoms

  Borderline Symptom List

  6 weeks

Secondary Outcomes (3)

• Depression

  6 weeks

• Anxiety

  6 weeks

• Positive Affect

  6 weeks

Other Outcomes (1)

• Heart rate variability

  6 weeks

Study Arms (2)

meditation

EXPERIMENTAL

Central Meditation and Imagery Therapy

Behavioral: Central Meditation and Imagery Therapy

wait list

NO INTERVENTION

waiting list

Interventions

Central Meditation and Imagery Therapy BEHAVIORAL

mindfulness, guided imagery, meditation

meditation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Meeting the diagnostic criteria for BPD according to DSM-IV criteria
• Meeting the diagnostic criteria for BPD based on the Diagnostic Interview for Borderline - Revised
• Currently receiving psychotherapy.
• English language proficiency to understand written and oral communication

You may not qualify if:

• Active suicidality or suicidal intent as identified on the Columbia Suicide Severity Rating Scale
• Suicide attempt within the past month

Sponsors & Collaborators

• University of California, San Francisco: lead

Study Sites (1)

University of California, Los Angeles

Los Angeles, California, 90095, United States

Location

Related Publications (1)

• Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2.

  PMID: 32368793 DERIVED

MeSH Terms

Conditions

Borderline Personality Disorder

Interventions

Imagery, Psychotherapy

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Felipe A Jain, MD

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 26, 2014
• First Posted: April 29, 2014
• Study Start: April 1, 2014
• Primary Completion: September 1, 2015
• Study Completion: September 1, 2015
• Last Updated: January 13, 2021

Record last verified: 2021-01

Locations

US (1)