Efficacy of Dialectical Behavior Therapy in Patients With Borderline Personality Disorder

NCT01952405 | Completed DMC

• 1 other identifier: NSC102-2314-B-195-002-My3
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test the hypothesis: Primary hypothesis: Participants in the dialectical behavior therapy group have greater reductions in the frequency and severity of suicidal and non-suicidal self-injurious behaviors compared to participants in the alternative treatment group. Secondary Hypotheses: Participants in dialectical behavior therapy group have improved treatment outcomes compared to participants in alternative treatment, including mental health service utilization, symptoms of borderline personality and depression symptoms, suicidal thought and hopelessness, disability, and quality of life.

Conditions

Borderline Personality Disorder

Outcome Measures

Primary Outcomes (1)

• Suicide Attempt Self-Injury Interview (SASII)

  change from baseline in Suicide Attempt Self-Injury Interview at 4 months, 8 months and 12 months

  4 months, 8 months and 12 months

Secondary Outcomes (10)

• Borderline Personality Disorder Subscale

  4 months, 8 months and 12 months

• Borderline Symptom Checklist (BSL-23)

  4 months, 8 months and 12 months

• The Patient Health Questionnaire (PHQ-9)

  4 months, 8 months and 12 months

• Symptom Checklist-90-Revised (SCL-90-R)

  4 months , 8 months and 12 months

• Beck Scale for Suicide Ideation (BSSI)

  4 months , 8months and 12 months

Other Outcomes (1)

• The SCAN (Schedules for Clinical Assessment in Neuropsychiatry)

  baseline assessment(0 month) and post-treatment (12-month)

Study Arms (2)

Dialectical behavior therapy

EXPERIMENTAL

Dialectical behavior therapy (DBT), developed by Marsha Linehan, has gained widespread popularity as a treatment for BPD, and its efficacy has been demonstrated in several trials.

Behavioral: Dialectical behavior therapy (DBT)

alternative psychotherapy

PLACEBO COMPARATOR

The therapists of the alternative psychotherapy in the comparison group are asked to provide the type and dose of therapy that they believed is most suited to the patient, with a minimum of 1 scheduled individual session per week. Ancillary treatment could be prescribed as needed. Case management strategies are also available in the comparison group (alternative psychotherapy group). No restrictions are placed on ancillary pharmacotherapy in either condition.

Behavioral: Dialectical behavior therapy (DBT)

Interventions

Dialectical behavior therapy (DBT) BEHAVIORAL

Dialectical behavior therapy (DBT), developed by Marsha Linehan, has gained widespread popularity as a treatment for BPD, and its efficacy has been demonstrated in several trials.

Dialectical behavior therapy; alternative psychotherapy

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• meeting DSM-IV criteria for borderline personality disorder
• years of age
• have had at least two episodes of suicidal or non-suicidal self-injurious episodes in the past 5 years,
• at least one episode of suicidal is in the 3 months preceding enrollment
• agreement to participate in evaluation of the program.

You may not qualify if:

• bipolar I disorder, delirium, dementia, mental retardation, or a diagnosis of substance dependence in the preceding 30 days
• living outside of Taipei area
• having any serious medical condition likely to require hospitalization within the next year (e.g. cancer)
• and having plans to leave the Taipei area in the next 1 year

Sponsors & Collaborators

• Mackay Memorial Hospital: lead
• National Science and Technology Council, Taiwan: collaborator

Study Sites (1)

Mackay Memorial Hospital

Taipei, Taiwan

Location

Related Publications (1)

• Witt KG, Hetrick SE, Rajaram G, Hazell P, Taylor Salisbury TL, Townsend E, Hawton K. Psychosocial interventions for self-harm in adults. Cochrane Database Syst Rev. 2021 Apr 22;4(4):CD013668. doi: 10.1002/14651858.CD013668.pub2.

  PMID: 33884617 DERIVED

Related Links

• Click here for more information about this study

MeSH Terms

Conditions

Borderline Personality Disorder

Interventions

Dialectical Behavior Therapy

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Chie Pein Chen, PHD

  Department of Medical Research, Mackay Memorial Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Visiting Staff

Study Record Dates

• First Submitted: September 6, 2013
• First Posted: September 30, 2013
• Study Start: May 18, 2013
• Primary Completion: February 24, 2017
• Study Completion: February 24, 2017
• Last Updated: March 6, 2017

Record last verified: 2017-03

Locations

TW (1)