Treadmill Walking in Individuals With Dementia With Lewy Bodies and Huntington's Disease

NCT02268617 | Completed

• 1 other identifier: 2012H0385
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Individuals with Dementia with Lewy Bodies (DLB) and Huntington's disease (HD) experience balance and walking problems that lead to falls. Treadmill walking has demonstrated improvements in balance and walking and fall risk in individuals with Parkinson's disease (PD), suggesting that it may be beneficial for individuals with DLB and HD. In PD subjects, changes in gait parameters have been noted after only one treadmill training session. The investigators propose a pilot study to investigate the safety, feasibility, and utility to improve mobility and fall risk of a single session of treadmill walking in individuals with DLB and HD.

Conditions

Huntington Disease; Lewy Body Disease

Keywords

Treadmill; Walking; Gait; Exercise

Outcome Measures

Primary Outcomes (1)

• Vital signs

  Blood pressure, heart rate, and rating of perceived exertion will be measured before, during, and after treadmill walking.

  Within 24 hours

Secondary Outcomes (3)

• Spatiotemporal gait measures

  within 24 hours

• Timed Up and Go Test

  Within 24 hours

• Q-motor testing

  Within 24 hours

Study Arms (1)

Treadmill Walking

EXPERIMENTAL

All subjects will walk on treadmill for a total of 20 minutes.

Other: Treadmill Walking

Interventions

Treadmill Walking OTHER

Following instructions and familiarization with the treadmill, participants will walk on the treadmill for 20 minutes total with rest periods as needed. Treadmill speed will be set at each participant's overground comfortable walking speed for the first 5 minutes, provided that they can walk safely. If necessary the speed will be lowered until a safe gait is achieved. After 5 minutes the speed will be incrementally increased by10% each 5 minutes (3 times) as long as a safe gait (i.e., no abnormal vital signs, excessive effort, or loss of balance occurrences) can be maintained. If the gait pattern becomes unsafe or more abnormal the speed will revert to the previous safe speed and be maintained at this level until the end of training session.

Treadmill Walking

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of Huntington's disease or Dementia with Lewy Bodies,
• the ability to ambulate 80 feet without assistance, and
• the ability to provide informed consent and understand directions.

You may not qualify if:

• presence of any clinically significant musculoskeletal or neurological disease that would affect gait.

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University Physical Therapy Division

Columbus, Ohio, 43210, United States

Location

Related Publications (5)

• Bello O, Sanchez JA, Fernandez-del-Olmo M. Treadmill walking in Parkinson's disease patients: adaptation and generalization effect. Mov Disord. 2008 Jul 15;23(9):1243-9. doi: 10.1002/mds.22069.

  PMID: 18464281 BACKGROUND

• Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA, Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology. 2010 Dec 14;75(24):2150-60. doi: 10.1212/WNL.0b013e3182020123. Epub 2010 Nov 10.

  PMID: 21068430 BACKGROUND

• Bilney B, Morris ME, Churchyard A, Chiu E, Georgiou-Karistianis N. Evidence for a disorder of locomotor timing in Huntington's disease. Mov Disord. 2005 Jan;20(1):51-7. doi: 10.1002/mds.20294.

  PMID: 15390128 BACKGROUND

• Churchyard AJ, Morris ME, Georgiou N, Chiu E, Cooper R, Iansek R. Gait dysfunction in Huntington's disease: parkinsonism and a disorder of timing. Implications for movement rehabilitation. Adv Neurol. 2001;87:375-85. No abstract available.

  PMID: 11347241 BACKGROUND

• Frenkel-Toledo S, Giladi N, Peretz C, Herman T, Gruendlinger L, Hausdorff JM. Treadmill walking as an external pacemaker to improve gait rhythm and stability in Parkinson's disease. Mov Disord. 2005 Sep;20(9):1109-14. doi: 10.1002/mds.20507.

  PMID: 15929090 BACKGROUND

MeSH Terms

Conditions

Huntington Disease; Lewy Body Disease; Motor Activity

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dementia; Chorea; Dyskinesias; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Parkinsonian Disorders; Synucleinopathies; Behavior

Study Officials

• Anne Kloos, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Clinical Professor

Study Record Dates

• First Submitted: October 10, 2014
• First Posted: October 20, 2014
• Study Start: February 1, 2013
• Primary Completion: August 1, 2016
• Study Completion: September 1, 2016
• Last Updated: September 27, 2016

Record last verified: 2016-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)