Move to Improve: Telehealth Exercise to Music for HD

NCT05270681 | Completed

• 1 other identifier: 2021H0219
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if a movement to music exercise program delivered via telehealth is feasible and safe for individuals with neurodegenerative disease and their caregivers (Aim 1). A secondary aim will be to determine if a movement to music exercise program delivered via telehealth improves balance, cognition, mobility, and quality of life (Aim 2).

Conditions

Huntington Disease

Keywords

Huntington; HD; Exercise; Telehealth; Dance

Outcome Measures

Primary Outcomes (19)

• Change in 4 stage balance test from baseline: feet together from baseline

  How long a participant can stand with feet together up to 10 seconds

  12 weeks

• Change in 4 stage balance test from baseline: feet together from baseline - TELEHEALTH

  How long a participant can stand with feet together up to 10 seconds collected via telehealth

  12 weeks

• Change in 4 stage balance test from baseline: feet staggered from baseline

  How long a participant can stand with feet staggered up to 10 seconds

  12 weeks

• Change in 4 stage balance test from baseline: feet staggered from baseline - TELEHEALTH

  How long a participant can stand with feet staggered up to 10 seconds collected via telehealth

  12 weeks

• Change in 4 stage balance test from baseline: feet in tandem from baseline

  How long a participant can stand with feet heel to toe up to 10 seconds

  12 weeks

• Change in 4 stage balance test from baseline: feet in tandem from baseline - TELEHEALTH

  How long a participant can stand with feet heel to toe up to 10 seconds collected via telehealth

  12 weeks

• Change in 4 stage balance test from baseline: single leg stance from baseline

  How long a participant can stand on one foot to toe up to 60 seconds

  12 weeks

• Change in 4 stage balance test from baseline: single leg stance from baseline - TELEHEALTH

  How long a participant can stand on one foot to toe up to 60 seconds collected via telehealth

  12 weeks

• Change in 5 Times Sit to Stand Test from baseline

  How long a participant can stand up and sit down from a standard chair with arms crossed across chest in seconds

  12 weeks

• Change in 5 Times Sit to Stand Test from baseline - TELEHEALTH

  How long a participant can stand up and sit down from a standard chair with arms crossed across chest in seconds collected via telehealth

  12 weeks

• Change in Adapted Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Questionnaire from baseline

  A patient-reported outcome measure that assesses perceived difficulty in completing physical tasks.

  12 weeks

• Change in Patient Health Questionnaire (PHQ-9) from baseline

  A self-administered instrument for depression module, which scores each of the items as "0" (not at all) to "3" (nearly every day), with higher scores indicating worse depression

  12 weeks

• Change in Patient Health Questionnaire (PHQ-9) from baseline - TELEHEALTH

  A self-administered instrument for depression module, which scores each of the items as "0" (not at all) to "3" (nearly every day), with higher scores indicating worse depression. Collected via telehealth

  12 weeks

• Change in 12-item Self-Report World Health Organization Disability Assessment Schedule (WHODAS) 2.0 questionnaire from baseline

  A patient reported outcome measure containing 12 items that the participant rates his or her difficulties in maintaining personal care, occupational tasks and functioning in relation to family and society with a score range from 12 to 60, where higher scores indicate higher disability or loss of function.

  12 weeks

• Change in 12-item Self-Report World Health Organization Disability Assessment Schedule (WHODAS) 2.0 questionnaire from baseline - TELEHEALTH

  A patient reported outcome measure containing 12 items that the participant rates his or her difficulties in maintaining personal care, occupational tasks and functioning in relation to family and society with a score range from 12 to 60, where higher scores indicate higher disability or loss of function. Collected via telehealth

  12 weeks

• Change in verbal fluency from baseline

  A measure of cognition that involves asking the participant to name as many animals as they can in 60 seconds and then they are given a letter and asked to name all of the words that begin with that letter in 60 seconds. The more words the better the outcome.

  12 weeks

• Change in verbal fluency from baseline - TELEHEALTH

  A measure of cognition that involves asking the participant to name as many animals as they can in 60 seconds and then they are given a letter and asked to name all of the words that begin with that letter in 60 seconds. The more words the better the outcome. Collected via telehealth.

  12 weeks

• Change in Digit Span test from baseline

  A measure of cognition that involves asking the participant to recall a series of numbers. The more numbers recalled accurately the better the outcome.

  12 weeks

• Change in Digit Span test from baseline - TELEHEALTH

  A measure of cognition that involves asking the participant to recall a series of numbers. The more numbers recalled accurately the better the outcome. Collected via telehealth

  12 weeks

Secondary Outcomes (5)

• Change in Unified Huntington's Disease Rating Scale (UHDRS) Motor Scale from baseline

  12 weeks

• Change in Unified Huntington's Disease Rating Scale (UHDRS) Functional Assessment scale from baseline

  12 weeks

• Change in Unified Huntington's Disease Rating Scale (UHDRS) Independence scale from baseline

  12 weeks

• Change in Symbol Digit Modality Test (SDMT) from baseline

  12 weeks

• Change in the Stroop interference test from baseline

  12 weeks

Other Outcomes (1)

• Open-ended questionnaire

  12 weeks

Study Arms (2)

Individuals with HD

EXPERIMENTAL

Participants with a confirmed diagnosis of Huntington's disease

Other: Movement to Music

Care Partners

EXPERIMENTAL

Participants' care partners

Other: Movement to Music

Interventions

Movement to Music OTHER

Participants will be educated on how to access prerecorded Move to Improve classes conducted by a professional dance instructor which will be accessible by computer or tablet 24/7 via a hyperlink. Classes last 45 minutes, and participants will be instructed to participate in the activity at least twice weekly, for 12 weeks. Each class uses movement to music combinations across different dance genres that build in intensity and sequence complexity, accompanied by music with faster beats, to encourage participants to achieve a moderate-vigorous level of physical and cognitive activity. Care partners will be present during each class to ensure safety and will also participate in the Move to Improve exercise program. The care partner and participant will be instructed to stand at a counter or behind a chair for safety during exercise.

Care Partners; Individuals with HD

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• confirmed diagnosis of a degenerative neurologic disorder such as HD, PD, mild dementia or mild cognitive impairment
• above the age of 21 years
• has a care partner who can assist with the program.
• able to access the online exercise program
• able to understand study and provide consent.
• stable medication regime for four weeks prior to initiation of trial, and anticipated to be able to maintain a stable regime for the course of trial
• OR regularly assisting in the care for an individual that meet the above criteria (for care partners)

You may not qualify if:

• any physical or psychiatric condition that would prohibit the participant from completing the intervention or the full battery of assessments
• unable to understand or communicate in spoken English
• currently involved in any intervention trial or within four weeks of completing an intervention trial
• current, regular participation in a structured exercise program three times per week or more

Sponsors & Collaborators

• Ohio State University: lead
• Huntington's Disease Society of America: collaborator

Study Sites (1)

The Ohio State University

Columbus, Ohio, 43210, United States

Location

MeSH Terms

Conditions

Huntington Disease; Motor Activity

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dementia; Chorea; Dyskinesias; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 25, 2022
• First Posted: March 8, 2022
• Study Start: November 8, 2021
• Primary Completion: November 14, 2024
• Study Completion: November 14, 2024
• Last Updated: July 30, 2025

Record last verified: 2025-07

Locations

US (1)