Huntington Disease
186
38
50
87
Key Insights
Highlights
Success Rate
88% trial completion (above average)
Published Results
21 trials with published results (11%)
Research Maturity
87 completed trials (47% of total)
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 50/100
6.5%
12 terminated out of 186 trials
87.9%
+1.4% vs benchmark
6%
12 trials in Phase 3/4
24%
21 of 87 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 87 completed trials
Clinical Trials (186)
Longitudinal SV2A PET and MRI in Premanifest HD
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease
Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease
Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease
Mass Balance Study of [14C] LPM3770164 in Healthy Participants
Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease
iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
Cognitive Assessment Tools for Huntington's Disease.
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease
Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease