Exercise Training and Fitness in Severe Obesity

NCT02254200 | Completed DMC

• 1 other identifier: 06C301
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is commonly associated with insulin resistance and hyperinsulinemia, which seem to be linked with an impaired ability to oxidize lipids, particularly in class III obese individuals \[Body Mass Index (BMI): \> 40 kg\*m-2\]. Exercise training is an effective strategy to improve insulin sensitivity and to reduce the risk of type 2 diabetes. This study aimed to compare the effects of two different 2-wk-long training modalities \[continuous at the intensity eliciting the maximal fat oxidation (Fatmax) versus adapted high intensity interval training (HIIT)\] on aerobic and metabolic fitness of class II and III obese men. It was hypothesized that, because of the nature of HIIT in the stimulation of rapid changes, aerobic fitness, fat oxidation rates during exercise and insulin sensitivity would be improved to a greater extent when adapted HIIT compared to Fatmax training.

Conditions

Obesity

Keywords

exercise; fat oxidation; indirect calorimetry; insulin sensitivity; weight management

Outcome Measures

Primary Outcomes (2)

• Maximal Oxygen consumption (VO2 max)

  VO2 max at incremental test performed at the end of Fatmax or HIIT training period

  After two-wk-long of Fatmax or HIIT traning

• Fat oxidation rates (FORs)

  FORs at incremental test performed at the end of Fatmax or HIIT training period

  After two-wk-long of Fatmax or HIIT traning

Secondary Outcomes (3)

• HOMA-IR

  After two-wk-long of Fatmax or HIIT traning

• Non-esterified fatty acid (NEFA)

  After two-wk-long of Fatmax or HIIT traning

• Insulin

  After two-wk-long of Fatmax or HIIT traning

Study Arms (2)

Fatmax group

EXPERIMENTAL

Group who performed a continuous training program at the intensity eliciting the maximal fat oxidation

Other: Fatmax group

HIIT group

EXPERIMENTAL

Group who performed a continuous training program with high intensity interval

Other: HIIT group

Interventions

Fatmax group OTHER

For the Fatmax group each session will consist of 40-50 min of continuous exercise with an intensity that corresponded to the individual Fatmax (moderate intensity)

Fatmax group

HIIT group OTHER

For HIIT group, each session will consist of 10x60-s cycling intervals interspersed with 60-s of recovery. The workloads will be selected to elicit a heart rate of \~90% maximal heart rate during the intervals with a pedal rate of 90-100 revolutions.min-1, whereas during recovery, the participants will be allowed to pedal against a resistance of 50 W

HIIT group

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI ≥ 35 kg\*m-2

You may not qualify if:

• Hypertension (blood pressure \> 130/90)
• Impaired fasting glucose (\> 6.1 mmol\*L-1)
• Type 2 diabetes
• Abnormal ECG readings at rest

Sponsors & Collaborators

• Istituto Auxologico Italiano: lead
• University of Lausanne: collaborator

Study Sites (1)

Istituto Auxologico Italiano, Ospedale San Giuseppe

Verbania, VB, 28921, Italy

Location

Related Publications (8)

• Houmard JA. Intramuscular lipid oxidation and obesity. Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1111-6. doi: 10.1152/ajpregu.00396.2007. Epub 2008 Feb 6.

  PMID: 18256136 BACKGROUND

• Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol (1985). 2004 Jan;96(1):101-6. doi: 10.1152/japplphysiol.00707.2003. Epub 2003 Sep 12.

  PMID: 12972442 BACKGROUND

• Dumortier M, Brandou F, Perez-Martin A, Fedou C, Mercier J, Brun JF. Low intensity endurance exercise targeted for lipid oxidation improves body composition and insulin sensitivity in patients with the metabolic syndrome. Diabetes Metab. 2003 Nov;29(5):509-18. doi: 10.1016/s1262-3636(07)70065-4.

  PMID: 14631328 BACKGROUND

• Bordenave S, Metz L, Flavier S, Lambert K, Ghanassia E, Dupuy AM, Michel F, Puech-Cathala AM, Raynaud E, Brun JF, Mercier J. Training-induced improvement in lipid oxidation in type 2 diabetes mellitus is related to alterations in muscle mitochondrial activity. Effect of endurance training in type 2 diabetes. Diabetes Metab. 2008 Apr;34(2):162-8. doi: 10.1016/j.diabet.2007.11.006.

  PMID: 18396088 BACKGROUND

• Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol. 2008 Jan 1;586(1):151-60. doi: 10.1113/jphysiol.2007.142109. Epub 2007 Nov 8.

  PMID: 17991697 BACKGROUND

• Whyte LJ, Gill JM, Cathcart AJ. Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men. Metabolism. 2010 Oct;59(10):1421-8. doi: 10.1016/j.metabol.2010.01.002. Epub 2010 Feb 12.

  PMID: 20153487 BACKGROUND

• Trilk JL, Singhal A, Bigelman KA, Cureton KJ. Effect of sprint interval training on circulatory function during exercise in sedentary, overweight/obese women. Eur J Appl Physiol. 2011 Aug;111(8):1591-7. doi: 10.1007/s00421-010-1777-z. Epub 2010 Dec 29.

  PMID: 21190036 BACKGROUND

• Lanzi S, Codecasa F, Cornacchia M, Maestrini S, Capodaglio P, Brunani A, Fanari P, Salvadori A, Malatesta D. Short-term HIIT and Fat max training increase aerobic and metabolic fitness in men with class II and III obesity. Obesity (Silver Spring). 2015 Oct;23(10):1987-94. doi: 10.1002/oby.21206. Epub 2015 Sep 3.

  PMID: 26335027 DERIVED

MeSH Terms

Conditions

Obesity; Motor Activity; Insulin Resistance

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Officials

• Stefano Lanzi, MSc

  University of Lausanne, Department of Physiology

  PRINCIPAL INVESTIGATOR

• Alberto Salvadori, MD

  Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

  STUDY DIRECTOR

• Franco Codecasa, MD

  Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

  PRINCIPAL INVESTIGATOR

• Mauro Cornacchia, MD

  Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

  STUDY CHAIR

• Davide Malatesta, PhD

  University of Lausanne, Institute of Sport Sciences

  STUDY DIRECTOR

• Paolo Fanari, MD

  Istituto Auxologico Italiano, Pulmonary Rehabilitation Department

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2014
• First Posted: October 1, 2014
• Study Start: January 1, 2013
• Primary Completion: December 1, 2013
• Study Completion: January 1, 2014
• Last Updated: July 21, 2015

Record last verified: 2015-07

Locations

IT (1)