Study of the Neural Basis of Analogical Reasoning

NCT02236832 | Completed

• 3 other identifiers: C14-17'140662B-312014-A00649-38
• Study Type: interventional
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Conditions

Frontotemporal Dementia; Progressive Supranuclear Palsy; Healthy Subjects

Outcome Measures

Primary Outcomes (2)

• Performance in the implicat task

  Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre.

  day of inclusion (one day)

• Performance in the Similitude task

  Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.

  from inclusion to 4 months after inclusion

Secondary Outcomes (2)

• recording of EEG

  day of inclusion (one day)

• Analysis of MRI

  day of inclusion (one day)

Study Arms (5)

FTD (frontotemporal dementia) patients

EXPERIMENTAL

fronto-temporal demential patients

Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination

PSP patients

EXPERIMENTAL

progressive supra nuclear palsy patients

Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination

healthy controls

ACTIVE COMPARATOR

healthy control education matched, age matched and sex matched with PSP and FTD patients

Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination

healthy participants

EXPERIMENTAL

healthy participants that will participate to the TMS study.

Device: transcranial magnetic stimulation; Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination

healthy young participants

EXPERIMENTAL

Healthy participants will be included for an EEG study

Other: EEG recording; Behavioral: Neuropsychological examination

Interventions

transcranial magnetic stimulation DEVICE

healthy participants

MRI imaging OTHER

FTD (frontotemporal dementia) patients; PSP patients; healthy controls; healthy participants

EEG recording OTHER

FTD (frontotemporal dementia) patients; PSP patients; healthy controls; healthy participants; healthy young participants

Neuropsychological examination BEHAVIORAL

FTD (frontotemporal dementia) patients; PSP patients; healthy controls; healthy participants; healthy young participants

Eligibility Criteria

• Age: 20 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy subjects:
• subject affiliated to national health insurance
• informed consent signed
• normal neurological examination
• subject aged at least 20
• Patients:
• FTD or PSP diagnostic criteria filled
• patient affiliated to national health insurance
• informed consent signed

You may not qualify if:

• Severe psychiatric symptomatology and psychotropic drug use
• unability to understand or perform the cognitive tasks.

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead
• Fondation pour la Recherche Médicale: collaborator

Study Sites (1)

ICM (Institut du cerveau et de la Moelle épinière)

Paris, 75013, France

Location

Related Publications (1)

• Ovando-Tellez M, Rohaut B, George N, Bieth T, Hugueville L, Ibrahim Y, Courbet O, Naccache L, Levy R, Garcin B, Volle E. Does adding <i>beer</i> to <i>coffee</i> enhance the activation of <i>drinks</i>? An ERP study of semantic category priming. Cogn Neurosci. 2022 Jan-Jun;13(2):61-76. doi: 10.1080/17588928.2021.1940117. Epub 2021 Jul 7.

  PMID: 34232829 BACKGROUND

MeSH Terms

Conditions

Frontotemporal Dementia; Supranuclear Palsy, Progressive

Interventions

Transcranial Magnetic Stimulation; Neuropsychological Tests

Condition Hierarchy (Ancestors)

Frontotemporal Lobar Degeneration; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; TDP-43 Proteinopathies; Neurodegenerative Diseases; Proteostasis Deficiencies; Metabolic Diseases; Nutritional and Metabolic Diseases; Neurocognitive Disorders; Mental Disorders; Basal Ganglia Diseases; Movement Disorders; Ophthalmoplegia; Ocular Motility Disorders; Cranial Nerve Diseases; Tauopathies; Paralysis; Neurologic Manifestations; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics; Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Richard Levy, MD, PhD

  Institut du Cerveau et de la Moelle épinière, Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 28, 2014
• First Posted: September 11, 2014
• Study Start: February 1, 2015
• Primary Completion: February 1, 2021
• Study Completion: February 1, 2021
• Last Updated: September 4, 2025

Record last verified: 2017-03

Locations

FR (1)