Treatment Drop-out and Missed Appointments Among Adults With ADHD

NCT02226445 | Completed

• 1 other identifier: ADHD/DO/MA
• Study Type: observational
• Target: 153
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators knowledge of factors associated with treatment drop-out and missed appointments among adults with Attention-Deficit/Hyperactivity Disorder (ADHD) within a naturalistic, clinical setting is very limited. Drop-out rates among adult ADHD patients in randomised controlled trials (RCT´s) have been reported to be 26.6% - 50%, and similar rates are reported in two naturalistic studies of medication adherence. Based on proposed hypotheses that past behaviour patterns are more predictive of current behaviours of treatment drop-out and missed appointments than are sociodemographic and clinical characteristics, the aim of the present study is to examine the associations of 1) sociodemographic variables, 2) clinical variables, 3) risk-taking behaviour 4) educational and occupational instability and 5) behaviours during primary/lower secondary school with treatment drop-out and number of missed appointments. The target group of the study consists of all patients who initiates assessment at the adult ADHD Clinic at Regional Psychiatric Services West, Herning, Central Denmark Region in the period from September 1, 2010 to September 1, 2011. The patients are referred to this Clinic from general practitioners and specialised psychiatric authorities. The investigators study is designed as an observational, cohort study in which the patients are offered medical and non-manualised psychosocial treatment as it is usually offered in this tertiary ADHD Clinic from which the data are collected. Data regarding sociodemography, clinical symptoms and impairments, risk-taking behaviour, educational and occupational instability and behaviours during primary/lower secondary school are collected using a semistructured protocol. In the investigators study the investigators define treatment drop-out as premature termination of ongoing treatment, without any prior clinical or agreed resolution. No standardized definition of treatment drop-out is used through out the literature of adherence to treatment among patients in the psychiatric care system.

Conditions

Attention-Deficit/Hyperactivity Disorder; Drop-out; Non-adherence

Keywords

Adults; Outpatients

Outcome Measures

Primary Outcomes (2)

• Treatment drop-out

  The outcome measure "treatment drop-out" is a binary outcome where participants at discharge are characterized as "drop-outs" or "non drop-outs". "Drop-outs" are defined as those participants, who terminate treatment without any prior clinical or agreed resolution. Logistic regression analyses is applied to calculate outcome odds ratios.

  Patients will be followed for the duration of outpatient treatment at the ADHD Clinic, an expected average of 1 year

• Missed appointments

  The outcome measure "missed appointments" is a binary outcome, dichomized into \<3 missed appointments during treatment and ≥3 missed appointments during treatment. Logistic regression analyses is applied to calculate outcome odds ratios.

  Patients will be followed for the duration of outpatient treatment at the ADHD Clinic, an expected average of 1 year

Study Arms (1)

ADHD medication and psychosocial counseling

Other: Combined ADHD medication and psychosocial counseling

Interventions

Combined ADHD medication and psychosocial counseling OTHER

The patients are offered as well ADHD medication as non-standardized psychosocial treatment, the latter including psychoeducation (i.e. information about ADHD aetiology and symptoms plus management of symptoms) and counselling regarding emotional-, family- and social rehabilitation-related problems. ADHD medication: First choice of medication is methylphenidate immediate release, initially 5 mg 2-3 times a day increasing with 10-20 mg per week up to stabilization of symptoms. When stabilized a shift to extended release methylphenidate. Alternatively dexamphetamine, initially 2.5 mg 2-3 times a day increasing with 5-10 mg per week up to stabilization of symptoms. If there is no adequate effect of central stimulants then a shift to atomoxetine, initially 18 mg a day, increasing during a period of 6-10 weeks up to max. 100 mg a day. If the patients have a substance use, an anxiety problem or other contraindications then first choice of medication is atomoxetine.

ADHD medication and psychosocial counseling

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to a tertiary ADHD Clinic at Regional Psychiatric Services West, Central Denmark Region

You may qualify if:

• Referred to the ADHD Clinic and initiating assessment between September 1, 2010 and September 1, 2011

You may not qualify if:

• No ADHD diagnosis as assessed by the ADHD Clinic

Sponsors & Collaborators

• University of Aarhus: lead
• Central Denmark Region: collaborator

Study Sites (1)

Psychiatric Research Unit West, Regional Psychiatric Services West

Herning, DK - 7400, Denmark

Location

Related Publications (1)

• Soendergaard HM, Thomsen PH, Pedersen P, Pedersen E, Poulsen AE, Nielsen JM, Winther L, Henriksen A, Rungoe B, Soegaard HJ. Treatment dropout and missed appointments among adults with attention-deficit/hyperactivity disorder: associations with patient- and disorder-related factors. J Clin Psychiatry. 2016 Feb;77(2):232-9. doi: 10.4088/JCP.14m09270.

  PMID: 26761266 DERIVED

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Hans Jørgen Søgaard, MD, Ph.d.

  Psychiatric Research Unit West, Regional Psychiatric Services West, Central Denmark Region

  STUDY CHAIR

• Helle Møller Søndergaard, MSc

  Psychiatric Research Unit West, Regional Psychiatric Services West, Central Denmark Region

  PRINCIPAL INVESTIGATOR

• Per Hove Thomsen, Professor

  Center for Child and Adolescent Psychiatry, Aarhus University Hospital, Central Denmark Region

  STUDY CHAIR

• Erik Pedersen, MD

  Regional Psychiatric Services West, Central Denmark Region

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 22, 2014
• First Posted: August 27, 2014
• Study Start: September 1, 2010
• Primary Completion: January 1, 2013
• Study Completion: January 1, 2013
• Last Updated: August 27, 2014

Record last verified: 2014-08

Locations

DK (1)