Multi-modality MRI Study on Differences in Conversion of aMCI Patients With APOEε4 to AD

NCT02225964 | Completed DMC

• 1 other identifier: XuanwuH 2
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study is to find out the imaging marker and the changing laws of the marker during the course of the disease. The final purpose is to provide scientific evidence for new prevention, diagnosis and treatment of Alzheimer's disease.

Conditions

Mild Cognitive Impairment

Keywords

APOEε4

Outcome Measures

Primary Outcomes (1)

• the conversion of aMCI patients with APOEε4 to AD

  According to situation of the conversion or non-conversion and differences in the conversion progression, we will analyze the data between the inter-groups and intra-groups, compare the imaging data of baseline and follow-up, find the prediction imaging marker of AD and optimize the reliability and validity.

  one year

Study Arms (1)

aMCIp,aMCIs

progressive aMCI,stable aMCI

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

aMCI patients with APOEε4

You may qualify if:

• Complaint about memory loss and confirmed by an informant
• Cognitive impairment in single or multiple domains, adjusted for age and education
• Normal or near-normal performance on general cognitive function and no or minimum impairment of daily life activities
• A Clinical Dementia Rating (CDR) score is 0.5
• Failure to meet the criteria for dementia
• Carrying susceptible gene APOEε4
• Must be able to accept examination of MRI, sight and hearing allow to complete test

You may not qualify if:

• Other diseases that cause cognitive impairment,such as thyroid disease,stroke and so on
• people who have severe visual and hearing impairment

Sponsors & Collaborators

• XuanwuH 2: lead
• Xuanwu Hospital, Beijing: collaborator

Study Sites (1)

Department of Neurolgy,Xuanwu Hospital of Capital Medical University

Beijing, Beijing Municipality, 100053, China

Location

Related Publications (3)

• Lin H, Li M, Zhan Y, Lin L, Yang K, Hu S, Han Y. Disrupted white matter functional connectivity in aMCI APOEepsilon4 carriers: a resting-state study. Brain Imaging Behav. 2021 Aug;15(4):1739-1747. doi: 10.1007/s11682-020-00367-7.

  PMID: 32715396 DERIVED

• Yang L, Yan Y, Wang Y, Hu X, Lu J, Chan P, Yan T, Han Y. Gradual Disturbances of the Amplitude of Low-Frequency Fluctuations (ALFF) and Fractional ALFF in Alzheimer Spectrum. Front Neurosci. 2018 Dec 20;12:975. doi: 10.3389/fnins.2018.00975. eCollection 2018.

  PMID: 30618593 DERIVED

• Chen GQ, Sheng C, Li YX, Yu Y, Wang XN, Sun Y, Li HY, Li XY, Xie YY, Han Y. Neuroimaging basis in the conversion of aMCI patients with APOE-epsilon4 to AD: study protocol of a prospective diagnostic trial. BMC Neurol. 2016 May 12;16:64. doi: 10.1186/s12883-016-0587-2.

  PMID: 27176479 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Chief physician

Study Record Dates

• First Submitted: August 24, 2014
• First Posted: August 26, 2014
• Study Start: January 1, 2014
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2018
• Last Updated: July 2, 2020

Record last verified: 2020-06

Locations

CN (1)