NCT02222142

Brief Summary

Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,080

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2010

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2010

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

August 17, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 21, 2014

Completed
Last Updated

August 21, 2014

Status Verified

August 1, 2014

Enrollment Period

2.9 years

First QC Date

August 17, 2014

Last Update Submit

August 20, 2014

Conditions

Off Pump Coronary Artery Bypass Graft

Keywords

Ischemic heart diseaseOff pump coronary artery bypass graftIsofluranePropofol

Outcome Measures

Primary Outcomes (1)

  • CK-MB, CRP

    Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2

    Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2

Secondary Outcomes (1)

  • Clinical adverse outcomes

    until 1 year after OPCAB

Other Outcomes (1)

  • Cardioprotection and clinical adverse outcomes in diabetic patients

    POD, POD 1, POD 2, one month, one year

Study Arms (2)

Isoflurane group

Isoflurane inhalational anesthesia during OPCAB

Drug: Isoflurane

Propofol group

Total intravenous anesthesia with propofol during OPCAB

Interventions

IsofluraneDRUG

Comparison between isoflurane and propofol, Retrospective study

Also known as: inhalational anesthetics
Isoflurane group

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients underwent OPCAB from January, 2010 to December, 2012

You may qualify if:

  • OPCAB

You may not qualify if:

  • On pump conversion

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Samsung medical center

Seoul, 135-710, South Korea

Location

MeSH Terms

Conditions

Myocardial Ischemia

Interventions

Isoflurane

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular DiseasesVascular Diseases

Intervention Hierarchy (Ancestors)

Methyl EthersEthersOrganic Chemicals

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor

Study Record Dates

First Submitted

August 17, 2014

First Posted

August 21, 2014

Study Start

January 1, 2010

Primary Completion

December 1, 2012

Study Completion

December 1, 2012

Last Updated

August 21, 2014

Record last verified: 2014-08

Locations

KR(1)