Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project
1 other identifier
interventional
1,584
1 country
1
Brief Summary
Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane. The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 17, 2011
CompletedFirst Posted
Study publicly available on registry
June 23, 2011
CompletedStudy Start
First participant enrolled
July 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedResults Posted
Study results publicly available
April 10, 2017
CompletedApril 10, 2017
February 1, 2017
1.8 years
June 17, 2011
November 29, 2016
February 25, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Hospital Length of Stay
participants will be followed for the duration of hospital stay, an expected average of 3 days
Secondary Outcomes (2)
Time-weighted Average Verbal Rating Pain Score
up to 72 hours after surgery
Total Intraoperative Opioid Consumption
intraoperative
Study Arms (2)
Isoflurane
EXPERIMENTALIsoflurane is to be administered to patients in this arm during surgery
Sevoflurane
EXPERIMENTALSevoflurane is to be administered to patients in this arm during surgery
Interventions
Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist
Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist
Eligibility Criteria
You may qualify if:
- Must have surgery in G operating room suite
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Cleveland Clinic
Cleveland, Ohio, 44195, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Daniel Sessler
- Organization
- Cleveland Clinic Foundation
Study Officials
- PRINCIPAL INVESTIGATOR
Daniel I Sessler, MD
The Cleveland Clinic
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor & Chair
Study Record Dates
First Submitted
June 17, 2011
First Posted
June 23, 2011
Study Start
July 1, 2011
Primary Completion
April 1, 2013
Study Completion
April 1, 2013
Last Updated
April 10, 2017
Results First Posted
April 10, 2017
Record last verified: 2017-02
Data Sharing
- IPD Sharing
- Will not share