NCT02214329

Brief Summary

Diabetic peripheral neuropathy (DPN) can severely deteriorate balance and gait in patients, thereby increasing risk of fall and injury. The aim of the study is to evaluate the efficacy of a virtual reality game based exercise training for improving postural body sway and gait in diabetes patients with peripheral neuropathy. The exercise training has been specifically designed for DPN patients with lost lower extremity joint perception and uses state-of-the-art inertial sensors (body-worn) to acquire joint movement and provide real-time joint feedback through an interactive interface on a LCD monitor. The investigators hypothesize that tailored exercise with real-time visual joint feedback during exercise will reduce improve balance and gait.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable diabetes

Timeline
Completed

Started Feb 2014

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2014

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

August 8, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 12, 2014

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2015

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2015

Completed
Last Updated

August 12, 2014

Status Verified

August 1, 2014

Enrollment Period

1.5 years

First QC Date

August 8, 2014

Last Update Submit

August 11, 2014

Conditions

Keywords

Postural BalanceGaitFall risk

Outcome Measures

Primary Outcomes (2)

  • Postural Balance

    Postural balance is assess at baseline and post-training using body-worn sensors

    6 weeks

  • Gait

    Gait is assessed at baseline and post-training using body-worn sensors

    6 weeks

Secondary Outcomes (2)

  • Physical Activity

    6 weeks

  • Functional Performance

    6 weeks

Study Arms (2)

Sensor-based exercise training

EXPERIMENTAL

The intervention group receives sensor-based balance training with real-time joint feedback through an interactive interface on LC monitor screen.

Device: Sensor-based exercise training

In-home balance training

ACTIVE COMPARATOR

The control group performs similar exercise as intervention group at home without use of sensor or any joint feedback from sensor data.

Other: In-home balance training

Interventions

Body-worn sensors are mounted on different body segments to acquire joint kinematic data and provide real-time joint feedback during exercise training.

Sensor-based exercise training

The control group performs similar exercise as intervention without sensors and with no visual feedback from sensors.

In-home balance training

Eligibility Criteria

Age50 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diabetic peripheral neuropathy
  • Age \> 50 (Men or Women)
  • Able to walk 60 feet

You may not qualify if:

  • Major lower extremity amputation
  • Cognitive deficits (MMSE 24 or below)
  • Severely impaired vision

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Medical Center

Tucson, Arizona, 85724, United States

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 8, 2014

First Posted

August 12, 2014

Study Start

February 1, 2014

Primary Completion

August 1, 2015

Study Completion

December 1, 2015

Last Updated

August 12, 2014

Record last verified: 2014-08

Locations