Adaptive Cognitive Training in Healthy Older Adults

NCT02205710 | Completed

• 1 other identifier: M16-14-018
• Study Type: interventional
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive training has emerged as a promising method to maintain, enhance, and rehabilitate cognitive function in older adults and individuals with dementia. In recent years, such training has become particularly appealing in the clinical context, with many paradigms aimed specifically at adults experiencing various stages of cognitive decline due to Mild Cognitive Impairment, Alzheimer's disease, and vascular dementias. However, basic questions remain. For example, uncertainty persists regarding factors that influence observed improvements as well as the conditions that would maximize transfer and sustainability of training effects. The objective of this study is to evaluate factors that may maximize the benefits of computerized cognitive training in older adults.

Conditions

Mild Cognitive Impairment; Mild to Moderate Dementia; Alzheimer's Disease

Outcome Measures

Primary Outcomes (3)

• Change in ratings on cognitive training survey

  This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7.

  Baseline, week 5

• Change in neural activity

  We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level.

  Baseline, week 5

• Change in performance on neuropsychological tests

  Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training.

  Baseline, week 5

Secondary Outcomes (1)

• Change in ratings of psychological wellbeing

  Baseline, week 5

Study Arms (2)

Computerized cognitive training

EXPERIMENTAL

Series of gamified tasks.

Other: Computerized cognitive training

Computerized game training

PLACEBO COMPARATOR

Series of gamified tasks.

Other: Computerized games

Interventions

Computerized cognitive training OTHER

Also known as: Activate

Computerized cognitive training

Computerized games OTHER

Computerized game training

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• English as the maternal or primary spoken language.
• Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease).
• Normal or corrected-to-normal vision and hearing.

You may not qualify if:

• Poor hearing or vision
• Inadequate understanding of the English language

Sponsors & Collaborators

• Bruyère Health Research Institute.: lead
• University of Ottawa: collaborator

Study Sites (1)

Bruyere Continuing Care

Ottawa, Ontario, K1N 5C8, Canada

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Alzheimer Disease

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases

Study Officials

• Patrick Davidson, PhD

  University of Ottawa

  PRINCIPAL INVESTIGATOR

• Sheida Rabipour, MSc

  University of Ottawa

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2014
• First Posted: July 31, 2014
• Study Start: August 1, 2016
• Primary Completion: August 1, 2018
• Study Completion: August 1, 2018
• Last Updated: August 2, 2019

Record last verified: 2017-08

Locations

CA (1)